![Anti-CCND3 antibody [6H4] (STJ97979)](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/124x110/products/120128/229673/STJ97979_2_ELISA__05913.1602854465.jpg?c=1 "Anti-CCND3 antibody [6H4] (STJ97979)")
![Anti-CCND3 antibody [6H4] (STJ97979)](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/1280x1280/products/120128/229673/STJ97979_2_ELISA__05913.1602854465.jpg?c=1 "Anti-CCND3 antibody [6H4] (STJ97979)")
Anti-CCND3 antibody [6H4] (STJ97979)
SPECIFICATIONS
ClonalityMonoclonal
HostMouse
ConjugationUnconjugated
IsotypeIgG1
ImmunogenPurified recombinant fragment of human Cyclin D3 expressed in E. Coli.
General Information
| Short Description | Mouse monoclonal anti-G1/S-specific cyclin-D3 for use in WB and ELISA in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Mouse |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | 6H4 |
| Isotype | IgG1 |
| Conjugation | Unconjugated |
| Purification | Affinity purification |
| Dilution Range | WB 1:500-1:2000ELISA 1:10000 |
| Formulation | Liquid in PBS containing 0.03% Sodium Azide, 0.5% BSA, 50% Glycerol. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | CCND3 |
| Gene ID | 896 |
| Uniprot ID | CCND3_HUMAN |
| Immunogen | Purified recombinant fragment of human Cyclin D3 expressed in E. Coli. |
| Specificity | Cyclin D3 Monoclonal Antibody detects endogenous levels of Cyclin D3 protein. |
Additional Info
| Function | Regulatory component of the cyclin D3-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Component of the ternary complex, cyclin D3/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex. Shows transcriptional coactivator activity with ATF5 independently of CDK4. |
| Protein Name | G1/S-Specific Cyclin-D3 |
| Database Links | Reactome: R-HSA-381340Reactome: R-HSA-5687128Reactome: R-HSA-69231Reactome: R-HSA-8934593Reactome: R-HSA-9661069Reactome: R-HSA-9754119 |
| Cellular Localisation | NucleusCytoplasm |
| Alternative Antibody Names | Anti-G1/S-Specific Cyclin-D3 antibodyAnti-CCND3 antibody |
Information sourced from Uniprot.org