| Host: | Rabbit |
| Applications: | WB/IHC-P/IF/ICC/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000 IHC-P:1:50-1:200 IF/ICC:1:50-1:200 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | CCNA2 |
| Gene ID: | 890 |
| Uniprot ID: | CCNA2_HUMAN |
| Immunogen Region: | 350-432 |
| Specificity: | A synthetic peptide corresponding to a sequence within amino acids 350-432 of human Cyclin A2 (NP_001228.1). |
| Immunogen Sequence: | YLPSVIAGAAFHLALYTVTG QSWPESLIRKTGYTLESLKP CLMDLHQTYLKAPQHAQQSI REKYKNSKYHGVSLLNPPET LNL |
| Post Translational Modifications | Polyubiquitinated via 'Lys-11'-linked ubiquitin by the anaphase-promoting complex (APC/C), leading to its degradation by the proteasome. Deubiquitinated and stabilized by USP37 enables entry into S phase. |
| Function | Cyclin which controls both the G1/S and the G2/M transition phases of the cell cycle. Functions through the formation of specific serine/threonine protein kinase holoenzyme complexes with the cyclin-dependent protein kinases CDK1 or CDK2. The cyclin subunit confers the substrate specificity of these complexes and differentially interacts with and activates CDK1 and CDK2 throughout the cell cycle. |
| Protein Name | Cyclin-A2 Cyclin-A Cyclin A |
| Database Links | Reactome: R-HSA-1362300 Reactome: R-HSA-1538133 Reactome: R-HSA-170145 Reactome: R-HSA-171319 Reactome: R-HSA-174184 Reactome: R-HSA-176408 Reactome: R-HSA-187577 Reactome: R-HSA-2559582 Reactome: R-HSA-2559586 Reactome: R-HSA-5689880 Reactome: R-HSA-5693607 Reactome: R-HSA-6804116 Reactome: R-HSA-6804756 Reactome: R-HSA-6804757 Reactome: R-HSA-68911 Reactome: R-HSA-68949 Reactome: R-HSA-69017 Reactome: R-HSA-69273 Reactome: R-HSA-69563 Reactome: R-HSA-69656 |
| Cellular Localisation | Nucleus Cytoplasm Exclusively Nuclear During Interphase Detected In The Nucleus And The Cytoplasm At Prophase Cytoplasmic When Associated With Scaper |
| Alternative Antibody Names | Anti-Cyclin-A2 antibody Anti-Cyclin-A antibody Anti-Cyclin A antibody Anti-CCNA2 antibody Anti-CCN1 antibody Anti-CCNA antibody |
Information sourced from Uniprot.org