| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Cholecystokinin (21-115) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.05% Proclin300, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:100-1:500 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
CCK |
| Gene ID: |
885 |
| Uniprot ID: |
CCKN_HUMAN |
| Immunogen Region: |
21-115 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 21-115 of human CCK (NP_000720.1). |
| Immunogen Sequence: |
QPVPPADPAGSGLQRAEEAP RRQLRVSQRTDGESRAHLGA LLARYIQQARKAPSGRMSIV KNLQNLDPSHRISDRDYMGW MDFGRRSAEEYEYPS |
| Tissue Specificity | Detected in cerebrospinal fluid and urine (at protein level). |
| Post Translational Modifications | The precursor is cleaved by proteases to produce a number of active cholecystokinins. Cholecystokinin-5: The precursor is cleaved by ACE, which removes the Gly-Arg-Arg peptide at the C-terminus, leading to mature hormone. |
| Function | This peptide hormone induces gall bladder contraction and the release of pancreatic enzymes in the gut. Its function in the brain is not clear. Binding to CCK-A receptors stimulates amylase release from the pancreas, binding to CCK-B receptors stimulates gastric acid secretion. |
| Protein Name | CholecystokininCck Cleaved Into - Cholecystokinin-58Cck58 - Cholecystokinin-58 Desnonopeptide(1-49-Cck58 - Cholecystokinin-39Cck39 - Cholecystokinin-33Cck33 - Cholecystokinin-25Cck25 - Cholecystokinin-18Cck18 - Cholecystokinin-12Cck12 - Cholecystokinin-8Cck8 - Cholecystokinin-7Cck7 - Cholecystokinin-5Cck5 |
| Database Links | Reactome: R-HSA-375276Reactome: R-HSA-416476 |
| Cellular Localisation | Secreted |
| Alternative Antibody Names | Anti-Cholecystokinin antibodyAnti-Cck Cleaved Into - Cholecystokinin-58 antibodyAnti-Cck58 - Cholecystokinin-58 Desnonopeptide antibodyAnti-(1-49-Cck58 - Cholecystokinin-39 antibodyAnti-Cck39 - Cholecystokinin-33 antibodyAnti-Cck33 - Cholecystokinin-25 antibodyAnti-Cck25 - Cholecystokinin-18 antibodyAnti-Cck18 - Cholecystokinin-12 antibodyAnti-Cck12 - Cholecystokinin-8 antibodyAnti-Cck8 - Cholecystokinin-7 antibodyAnti-Cck7 - Cholecystokinin-5 antibodyAnti-Cck5 antibodyAnti-CCK antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
