| Host: | Rabbit |
| Applications: | WB/IF/ICC/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.05% Proclin300, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | CBS |
| Gene ID: | 102724560/875 |
| Uniprot ID: | CBS_HUMAN |
| Immunogen Region: | 1-551 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-384 of human CBS (NP_000062.1). |
| Immunogen Sequence: | MPSETPQAEVGPTGCPHRSG PHSAKGSLEKGSPEDKEAKE PLWIRPDAPSRCTWQLGRPA SESPHHHTAPAKSPKILPDI LKKIGDTPMVRINKIGKKFG LKCELLAKCEFFNAGGSVKD RISLRMIEDAERDGTLKPGD TIIEPTSGNTGIGLALAAAV RGYRCIIVMPEKMSSEKVDV LRALGAEIVRTPTNARFDSP ESHVGVAWRLKNEIPNSHIL DQYRNASNPLAHYDTTADE |
| Tissue Specificity | In the adult strongly expressed in liver and pancreas, some expression in heart and brain, weak expression in lung and kidney. In the fetus, expressed in brain, liver and kidney. |
| Function | Hydro-lyase catalyzing the first step of the transsulfuration pathway, where the hydroxyl group of L-serine is displaced by L-homocysteine in a beta-replacement reaction to form L-cystathionine, the precursor of L-cysteine. This catabolic route allows the elimination of L-methionine and the toxic metabolite L-homocysteine. Also involved in the production of hydrogen sulfide, a gasotransmitter with signaling and cytoprotective effects on neurons. |
| Protein Name | Cystathionine Beta-SynthaseBeta-ThionaseSerine Sulfhydrase |
| Database Links | Reactome: R-HSA-1614603Reactome: R-HSA-2408508 |
| Cellular Localisation | CytoplasmNucleus |
| Alternative Antibody Names | Anti-Cystathionine Beta-Synthase antibodyAnti-Beta-Thionase antibodyAnti-Serine Sulfhydrase antibodyAnti-CBS antibody |
Information sourced from Uniprot.org
