Western blot analysis of extracts of various cell lines, using CBR3 antibody (STJ29683) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. Lysates/proteins: 25 Mu g per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 30s.

Anti-CBR3 antibody (118-277) (STJ29683)

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STJ29683
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Host: Rabbit
Applications: WB/ELISA
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Clonality : Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3.
Purification: Affinity purification
Concentration: Lot specific
Dilution Range: WB:1:500-1:2000
ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements.
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: CBR3
Gene ID: 874
Uniprot ID: CBR3_HUMAN
Immunogen Region: 118-277
Specificity: Recombinant fusion protein containing a sequence corresponding to amino acids 118-277 of human CBR3 (NP_001227.1).
Immunogen Sequence: TRNMCNELLPIMKPHGRVVN ISSLQCLRAFENCSEDLQER FHSETLTEGDLVDLMKKFVE DTKNEVHEREGWPNSPYGVS KLGVTVLSRILARRLDEKRK ADRILVNACCPGPVKTDMDG KDSIRTVEEGAETPVYLALL PPDATEPQGQLVHDKVVQNW
Tissue Specificity Detected in ovary, pancreas, intestine, colon, kidney, brain, thymus, lung, heart, liver, spleen, leukocyte, prostate and testis.
Function Catalyzes the NADPH-dependent reduction of carbonyl compounds to their corresponding alcohols. Has low NADPH-dependent oxidoreductase activity. Acts on several orthoquinones, acts as well on non-quinone compounds, such as isatin or on the anticancer drug oracin. Best substrates for CBR3 is 1,2- naphthoquinone, hence could play a role in protection against cytotoxicity of exogenous quinones. Exerts activity toward ortho-quinones but not paraquinones. No endogenous substrate for CBR3 except isatin has been identified.
Protein Name Carbonyl Reductase Nadph 3
Nadph-Dependent Carbonyl Reductase 3
Quinone Reductase Cbr3
Short Chain Dehydrogenase/Reductase Family 21c Member 2
Database Links Reactome: R-HSA-211945
Cellular Localisation Cytoplasm
Alternative Antibody Names Anti-Carbonyl Reductase Nadph 3 antibody
Anti-Nadph-Dependent Carbonyl Reductase 3 antibody
Anti-Quinone Reductase Cbr3 antibody
Anti-Short Chain Dehydrogenase/Reductase Family 21c Member 2 antibody
Anti-CBR3 antibody
Anti-SDR21C2 antibody

Information sourced from Uniprot.org

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