| Post Translational Modifications | Phosphorylated on tyrosine and serine residues upon TCR or BCR activation, and upon various types of cell stimulation. Auto-ubiquitinated upon EGF-mediated cell activation or upon T-cell costimulation by CD28.which promotes proteasomal degradation. |
| Function | E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and transfers it to substrates, generally promoting their degradation by the proteasome. Negatively regulates TCR (T-cell receptor), BCR (B-cell receptor) and FCER1 (high affinity immunoglobulin epsilon receptor) signal transduction pathways. In naive T-cells, inhibits VAV1 activation upon TCR engagement and imposes a requirement for CD28 costimulation for proliferation and IL-2 production. Also acts by promoting PIK3R1/p85 ubiquitination, which impairs its recruitment to the TCR and subsequent activation. In activated T-cells, inhibits PLCG1 activation and calcium mobilization upon restimulation and promotes anergy. In B-cells, acts by ubiquitinating SYK and promoting its proteasomal degradation. Slightly promotes SRC ubiquitination. May be involved in EGFR ubiquitination and internalization. May be functionally coupled with the E2 ubiquitin-protein ligase UB2D3. In association with CBL, required for proper feedback inhibition of ciliary platelet-derived growth factor receptor-alpha (PDGFRA) signaling pathway via ubiquitination and internalization of PDGFRA. |
| Protein Name | E3 Ubiquitin-Protein Ligase Cbl-BCasitas B-Lineage Lymphoma Proto-Oncogene BRing Finger Protein 56Ring-Type E3 Ubiquitin Transferase Cbl-BSh3-Binding Protein Cbl-BSignal Transduction Protein Cbl-B |
| Database Links | Reactome: R-HSA-983168 |
| Cellular Localisation | CytoplasmUpon Egf StimulationAssociates With Endocytic Vesicles |
| Alternative Antibody Names | Anti-E3 Ubiquitin-Protein Ligase Cbl-B antibodyAnti-Casitas B-Lineage Lymphoma Proto-Oncogene B antibodyAnti-Ring Finger Protein 56 antibodyAnti-Ring-Type E3 Ubiquitin Transferase Cbl-B antibodyAnti-Sh3-Binding Protein Cbl-B antibodyAnti-Signal Transduction Protein Cbl-B antibodyAnti-CBLB antibodyAnti-RNF56 antibodyAnti-Nbla00127 antibody |
Information sourced from Uniprot.org
