| Short Description : | Rabbit polyclonal Caveolae-Associated Protein 2 (325-425) antibody for use in WB, IHC-P and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications: | WB/IHC-P/ELISA |
| Host: | Rabbit |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Concentration: | Lot specific |
| Purification: | Affinity purification |
| Dilution Range: | WB:1:500-1:1000IHC-P:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation: | PBS with 0.05% Proclin300, 50% Glycerol, pH 7.3. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | CAVIN2 |
| Gene ID: | 8436 |
| Uniprot ID: | CAVN2_HUMAN |
| Immunogen Region: | 325-425 |
| Immunogen Sequence: | PNDQEEESFAEGHSEASLAS ALVEGEIAEEAAEKATSRGS NSGMDSNIDLTIVEDEEEES VALEQAQKVRYEGSYALTSE EAERSDGDPVQPAVLQVHQT S |
| Specificity: | A synthetic peptide corresponding to a sequence within amino acids 325-425 of human CAVIN2 ( NP_004648.1 ). |
| Tissue Specificity | Highly expressed in heart and lung, and expressed at lower levels in brain, kidney, liver, pancreas, placenta, and skeletal muscle. |
| Post Translational Modifications | Phosphorylated on Ser residues. |
| Function | Plays an important role in caveolar biogenesis and morphology. Regulates caveolae morphology by inducing membrane curvature within caveolae. Plays a role in caveola formation in a tissue-specific manner. Required for the formation of caveolae in the lung and fat endothelia but not in the heart endothelia. Negatively regulates the size or stability of CAVIN complexes in the lung endothelial cells. May play a role in targeting PRKCA to caveolae. |
| Protein Name | Caveolae-Associated Protein 2Cavin-2Ps-P68Phosphatidylserine-Binding ProteinSerum Deprivation-Response Protein |
| Database Links | |
| Cellular Localisation | CytoplasmCytosolMembraneCaveolaLocalizes In The Caveolae In A Caveolin-Dependent Manner |
| Alternative Antibody Names | Anti-Caveolae-Associated Protein 2 antibodyAnti-Cavin-2 antibodyAnti-Ps-P68 antibodyAnti-Phosphatidylserine-Binding Protein antibodyAnti-Serum Deprivation-Response Protein antibodyAnti-CAVIN2 antibodyAnti-SDPR antibody |
Information sourced from Uniprot.org
