• Western blot analysis of lysates from HeLa cells, using Caspase 10 Antibody. The lane on the right is blocked with the synthesized peptide.
  • Immunofluorescence analysis of HeLa cells, using Caspase 10 Antibody. The picture on the right is blocked with the synthesized peptide.
  • Immunohistochemistry analysis of paraffin-embedded human lung carcinoma tissue, using Caspase 10 Antibody. The picture on the right is blocked with the synthesized peptide.
  • Western blot analysis of various cells using Caspase-10 B/C Polyclonal Antibody

Anti-Caspase-10 B/C antibody (430-479 aa) (STJ92018)

SKU:
STJ92018

$62.10 - $305.10
Current Stock:
Host: Rabbit
Applications: WB/IHC/IF/ELISA
Reactivity: Human/Rat/Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-Caspase-10 and NA (430-479 aa) is suitable for use in Western Blot, Immunohistochemistry, Immunofluorescence and ELISA research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: WB 1:500-1:2000
IHC 1:100-1:300
IF 1:200-1:1000
ELISA 1:10000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: CASP10
Gene ID: 843
Uniprot ID: CASPA_HUMAN
Immunogen Region: 430-479 aa
Specificity: Caspase-10 B/D Polyclonal Antibody detects endogenous levels of proCaspase-10 B/D protein, actived Caspase-10 (isoform B and D) and Caspase-10 (isoform B and D) subunit p12
Immunogen: The antiserum was produced against synthesized peptide derived from the human Caspase 10 at the amino acid range 430-479
Post Translational Modifications Cleavage by granzyme B and autocatalytic activity generate the two active subunits.
Function Involved in the activation cascade of caspases responsible for apoptosis execution. Recruited to both Fas- and TNFR-1 receptors in a FADD dependent manner. May participate in the granzyme B apoptotic pathways. Cleaves and activates effector caspases CASP3, CASP4, CASP6, CASP7, CASP8 and CASP9. Hydrolyzes the small- molecule substrates, Tyr-Val-Ala-Asp-|-AMC and Asp-Glu-Val-Asp-|-AMC. Isoform 7 can enhance NF-kappaB activity but promotes only slight apoptosis. Isoform C is proteolytically inactive.
Protein Name Caspase-10
Casp-10
Apoptotic Protease Mch-4
Fas-Associated Death Domain Protein Interleukin-1b-Converting Enzyme 2
Flice2
Ice-Like Apoptotic Protease 4 Cleaved Into - Caspase-10 Subunit P23/17 - Caspase-10 Subunit P12
Database Links Reactome: R-HSA-6803207
Reactome: R-HSA-75157
Reactome: R-HSA-75158
Reactome: R-HSA-933543
Alternative Antibody Names Anti-Caspase-10 antibody
Anti-Casp-10 antibody
Anti-Apoptotic Protease Mch-4 antibody
Anti-Fas-Associated Death Domain Protein Interleukin-1b-Converting Enzyme 2 antibody
Anti-Flice2 antibody
Anti-Ice-Like Apoptotic Protease 4 Cleaved Into - Caspase-10 Subunit P23/17 - Caspase-10 Subunit P12 antibody
Anti-CASP10 antibody
Anti-MCH4 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance