| Host: |
Rabbit |
| Applications: |
WB/ELISA |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: |
Affinity purification |
| Concentration: |
Lot specific |
| Dilution Range: |
WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
CASP2 |
| Gene ID: |
835 |
| Uniprot ID: |
CASP2_HUMAN |
| Immunogen Region: |
153-452 |
| Specificity: |
Recombinant fusion protein containing a sequence corresponding to amino acids 153-452 of human Caspase-2 (NP_116764.2). |
| Immunogen Sequence: |
KLRLSTDTVEHSLDNKDGPV CLQVKPCTPEFYQTHFQLAY RLQSRPRGLALVLSNVHFTG EKELEFRSGGDVDHSTLVTL FKLLGYDVHVLCDQTAQEMQ EKLQNFAQLPAHRVTDSCIV ALLSHGVEGAIYGVDGKLLQ LQEVFQLFDNANCPSLQNKP KMFFIQACRGDETDRGVDQQ DGKNHAGSPGCEESDAGKEK LPKMRLPTRSDMICGYACLK GTAAMRNTKRGSWYIEALA |
| Tissue Specificity | Expressed at higher levels in the embryonic lung, liver and kidney than in the heart and brain. In adults, higher level expression is seen in the placenta, lung, kidney, and pancreas than in the heart, brain, liver and skeletal muscle. |
| Post Translational Modifications | The mature protease can process its own propeptide, but not that of other caspases. |
| Function | Is a regulator of the cascade of caspases responsible for apoptosis execution. Might function by either activating some proteins required for cell death or inactivating proteins necessary for cell survival. Associates with PIDD1 and CRADD to form the PIDDosome, a complex that activates CASP2 and triggers apoptosis in response to genotoxic stress. Isoform 1: Acts as a positive regulator of apoptosis. Isoform 2: Acts as a negative regulator of apoptosis. Isoform 3: May function as an endogenous apoptosis inhibitor that antagonizes caspase activation and cell death. |
| Protein Name | Caspase-2Casp-2Neural Precursor Cell Expressed Developmentally Down-Regulated Protein 2Nedd-2Protease Ich-1 Cleaved Into - Caspase-2 Subunit P18 - Caspase-2 Subunit P13 - Caspase-2 Subunit P12 |
| Database Links | Reactome: R-HSA-168638Reactome: R-HSA-205025Reactome: R-HSA-6803207 |
| Alternative Antibody Names | Anti-Caspase-2 antibodyAnti-Casp-2 antibodyAnti-Neural Precursor Cell Expressed Developmentally Down-Regulated Protein 2 antibodyAnti-Nedd-2 antibodyAnti-Protease Ich-1 Cleaved Into - Caspase-2 Subunit P18 - Caspase-2 Subunit P13 - Caspase-2 Subunit P12 antibodyAnti-CASP2 antibodyAnti-ICH1 antibodyAnti-NEDD2 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
