| Host: |
Rabbit |
| Applications: |
WB/IHC |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-F-actin-uncapping protein LRRC16A (853-903 aa) is suitable for use in Western Blot and Immunohistochemistry research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
WB 1:500-2000IHC-P 1:50-300 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
CARMIL1 |
| Gene ID: |
55604 |
| Uniprot ID: |
CARL1_HUMAN |
| Immunogen Region: |
853-903 aa |
| Specificity: |
This antibody detects endogenous levels of LR16A at Human/Mouse |
| Immunogen: |
Synthesized peptide derived from the human LR16A at the amino acid range 853-903 |
| Function | Cell membrane-cytoskeleton-associated protein that plays a role in the regulation of actin polymerization at the barbed end of actin filaments. Prevents F-actin heterodimeric capping protein (CP) activity at the leading edges of migrating cells, and hence generates uncapped barbed ends and enhances actin polymerization, however, seems unable to nucleate filaments. Plays a role in lamellipodial protrusion formations and cell migration. |
| Protein Name | F-Actin-Uncapping Protein Lrrc16aCarmil HomologCapping Protein Regulator And Myosin 1 Linker Protein 1Capping Protein - Arp2/3 And Myosin-I Linker Homolog 1Capping Protein - Arp2/3 And Myosin-I Linker Protein 1Leucine-Rich Repeat-Containing Protein 16a |
| Database Links | Reactome: R-HSA-983231 |
| Cellular Localisation | CytoplasmCytoskeletonCell MembraneCell ProjectionLamellipodiumFound On MacropinosomesColocalized With Heterodimeric Capping Protein (Cp) And F-Actin In Lamellipodia But Not With F-Actin In Stress Fibers |
| Alternative Antibody Names | Anti-F-Actin-Uncapping Protein Lrrc16a antibodyAnti-Carmil Homolog antibodyAnti-Capping Protein Regulator And Myosin 1 Linker Protein 1 antibodyAnti-Capping Protein - Arp2/3 And Myosin-I Linker Homolog 1 antibodyAnti-Capping Protein - Arp2/3 And Myosin-I Linker Protein 1 antibodyAnti-Leucine-Rich Repeat-Containing Protein 16a antibodyAnti-CARMIL1 antibodyAnti-CARMIL antibodyAnti-LRRC16 antibodyAnti-LRRC16A antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
