| Function | Cell membrane-cytoskeleton-associated protein that plays a role in the regulation of actin polymerization at the barbed end of actin filaments. Prevents F-actin heterodimeric capping protein (CP) activity at the leading edges of migrating cells, and hence generates uncapped barbed ends and enhances actin polymerization, however, seems unable to nucleate filaments. Plays a role in lamellipodial protrusion formations and cell migration. |
| Protein Name | F-Actin-Uncapping Protein Lrrc16aCarmil HomologCapping Protein Regulator And Myosin 1 Linker Protein 1Capping Protein - Arp2/3 And Myosin-I Linker Homolog 1Capping Protein - Arp2/3 And Myosin-I Linker Protein 1Leucine-Rich Repeat-Containing Protein 16a |
| Database Links | Reactome: R-HSA-983231 |
| Cellular Localisation | CytoplasmCytoskeletonCell MembraneCell ProjectionLamellipodiumFound On MacropinosomesColocalized With Heterodimeric Capping Protein (Cp) And F-Actin In Lamellipodia But Not With F-Actin In Stress Fibers |
| Alternative Antibody Names | Anti-F-Actin-Uncapping Protein Lrrc16a antibodyAnti-Carmil Homolog antibodyAnti-Capping Protein Regulator And Myosin 1 Linker Protein 1 antibodyAnti-Capping Protein - Arp2/3 And Myosin-I Linker Homolog 1 antibodyAnti-Capping Protein - Arp2/3 And Myosin-I Linker Protein 1 antibodyAnti-Leucine-Rich Repeat-Containing Protein 16a antibodyAnti-CARMIL1 antibodyAnti-CARMIL antibodyAnti-LRRC16 antibodyAnti-LRRC16A antibody |
Information sourced from Uniprot.org
