| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-CARD16 (50-150) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
CARD16 |
| Gene ID: |
114769 |
| Uniprot ID: |
CAR16_HUMAN |
| Immunogen Region: |
50-150 |
| Immunogen: |
A synthetic peptide corresponding to a sequence within amino acids 50-150 of human CARD16 (NP_001017534.1). |
| Immunogen Sequence: |
VMDKTRALIDSVIPKGAQAC QICITYICEEDSYLAETLGL SAALQAVQDNPAMPTCSSPE GRIKLCFLEDAQRIWKQKLQ RCHVQNTIIKWSERYTSGSF E |
| Tissue Specificity | Widely expressed. Expressed at higher level in placenta, spleen, lymph node and bone marrow. Weakly or not expressed in thymus. |
| Function | Caspase inhibitor. Acts as a regulator of procaspase-1/CASP1 activation implicated in the regulation of the proteolytic maturation of pro-interleukin-1 beta (IL1B) and its release during inflammation. Inhibits the release of IL1B in response to LPS in monocytes. Also induces NF-kappa-B activation during the pro-inflammatory cytokine response. Also able to inhibit CASP1-mediated neuronal cell death, TNF-alpha, hypoxia-, UV-, and staurosporine-mediated cell death but not ER stress-mediated cell death. Acts by preventing activation of caspases CASP1 and CASP4, possibly by preventing the interaction between CASP1 and RIPK2. |
| Protein Name | Caspase Recruitment Domain-Containing Protein 16Caspase Recruitment Domain-Only Protein 1Card-Only Protein 1Caspase-1 Inhibitor CopPseudo Interleukin-1 Beta Converting EnzymePseudo-IcePseudo-Il1b-Converting Enzyme |
| Alternative Antibody Names | Anti-Caspase Recruitment Domain-Containing Protein 16 antibodyAnti-Caspase Recruitment Domain-Only Protein 1 antibodyAnti-Card-Only Protein 1 antibodyAnti-Caspase-1 Inhibitor Cop antibodyAnti-Pseudo Interleukin-1 Beta Converting Enzyme antibodyAnti-Pseudo-Ice antibodyAnti-Pseudo-Il1b-Converting Enzyme antibodyAnti-CARD16 antibodyAnti-COP antibodyAnti-COP1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
