| Function | G protein-coupled receptor activated by ligand peptides amylin (IAPP), calcitonin (CT/CALCA) and calcitonin gene-related peptide type 1 (CGRP1/CALCA). CALCR interacts with receptor-activity-modifying proteins RAMP1, 2 and 3 to form receptor complexes AMYR1, 2 and 3, respectively. IAPP, CT and CGRP1 activate CALCR and AMYRs with distinct modes of receptor activation resulting in specific phenotypes. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors. Activates cAMP-dependent pathway. Isoform 2: Non-functional protein. Unable to couple to G proteins and activate adenylyl cyclase. Does not undergo receptor internalization following ligand binding. |
| Protein Name | Calcitonin ReceptorCt-R |
| Database Links | Reactome: R-HSA-418555Reactome: R-HSA-419812 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Calcitonin Receptor antibodyAnti-Ct-R antibodyAnti-CALCR antibody |
Information sourced from Uniprot.org
