| Host: |
Rabbit |
| Applications: |
WB/ELISA |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: |
Affinity purification |
| Concentration: |
Lot specific |
| Dilution Range: |
WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
CALCR |
| Gene ID: |
799 |
| Uniprot ID: |
CALCR_HUMAN |
| Immunogen Region: |
25-148 |
| Specificity: |
Recombinant fusion protein containing a sequence corresponding to amino acids 25-148 of human CALCR (NP_001733.1). |
| Immunogen Sequence: |
AFSNQTYPTIEPKPFLYVVG RKKMMDAQYKCYDRMQQLPA YQGEGPYCNRTWDGWLCWDD TPAGVLSYQFCPDYFPDFDP SEKVTKYCDEKGVWFKHPEN NRTWSNYTMCNAFTPEKLKN AYVL |
| Function | G protein-coupled receptor activated by ligand peptides amylin (IAPP), calcitonin (CT/CALCA) and calcitonin gene-related peptide type 1 (CGRP1/CALCA). CALCR interacts with receptor-activity-modifying proteins RAMP1, 2 and 3 to form receptor complexes AMYR1, 2 and 3, respectively. IAPP, CT and CGRP1 activate CALCR and AMYRs with distinct modes of receptor activation resulting in specific phenotypes. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors. Activates cAMP-dependent pathway. Isoform 2: Non-functional protein. Unable to couple to G proteins and activate adenylyl cyclase. Does not undergo receptor internalization following ligand binding. |
| Protein Name | Calcitonin ReceptorCt-R |
| Database Links | Reactome: R-HSA-418555Reactome: R-HSA-419812 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Calcitonin Receptor antibodyAnti-Ct-R antibodyAnti-CALCR antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
