Anti-CACNA2D2 antibody (20-200) (STJ112305)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal CACNA2D2 (20-200) antibody for use in WB and ELISA in mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:200-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | CACNA2D2 |
| Gene ID | 9254 |
| Uniprot ID | CA2D2_HUMAN |
| Immunogen Region | 20-200 |
| Immunogen Sequence | RPWPGCGPHPGPGTRRPTSG PPRPLWLLLPLLPLLAAPGA SAYSFPQQHTMQHWARRLEQ EVDGVMRIFGGVQQLREIYK DNRNLFEVQENEPQKLVEKV AGDIESLLDRKVQALKRLAD AAENFQKAHRWQDNIKEEDI VYYDAKADAELDDPESEDVE RGSKASTLRLDFIEDPNFKN K |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 20-200 of human CACNA2D2 (NP_001167522.1). |
Additional Info
| Tissue Specificity | Predominantly present in cerebellar cortex. Present in various lung tumor cell lines, while it is absent in normal lung (at protein level). Highly expressed in heart, lung, testis, pancreas and skeletal muscle. Also expressed in kidney, liver, placenta and brain. |
| Post Translational Modifications | May be proteolytically processed into subunits alpha-2-2 and delta-2 that are disulfide-linked. It is however unclear whether such cleavage really takes place in vivo and has a functional role. |
| Function | The alpha-2/delta subunit of voltage-dependent calcium channels regulates calcium current density and activation/inactivation kinetics of the calcium channel. Acts as a regulatory subunit for P/Q-type calcium channel (CACNA1A), N-type (CACNA1B), L-type (CACNA1C OR CACNA1D) and possibly T-type (CACNA1G). Overexpression induces apoptosis. |
| Protein Name | Voltage-Dependent Calcium Channel Subunit Alpha-2/Delta-2Voltage-Gated Calcium Channel Subunit Alpha-2/Delta-2 Cleaved Into - Voltage-Dependent Calcium Channel Subunit Alpha-2-2 - Voltage-Dependent Calcium Channel Subunit Delta-2 |
| Database Links | Reactome: R-HSA-112308Reactome: R-HSA-400042Reactome: R-HSA-422356Reactome: R-HSA-5576892Reactome: R-HSA-5576893Reactome: R-HSA-9662360 |
| Cellular Localisation | MembraneSingle-Pass Type I Membrane ProteinColocalizes With Cacna1a In Lipid Raft Fractions |
| Alternative Antibody Names | Anti-Voltage-Dependent Calcium Channel Subunit Alpha-2/Delta-2 antibodyAnti-Voltage-Gated Calcium Channel Subunit Alpha-2/Delta-2 Cleaved Into - Voltage-Dependent Calcium Channel Subunit Alpha-2-2 - Voltage-Dependent Calcium Channel Subunit Delta-2 antibodyAnti-CACNA2D2 antibodyAnti-KIAA0558 antibody |
Information sourced from Uniprot.org