| Host: | Rabbit |
| Applications: | IHC/WB |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-CACNA2D2 (560-610 aa) is suitable for use in Immunohistochemistry and Western Blot research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Lyophilised |
| Purification: | IgG purified |
| Dilution Range: | IHC, WB (confirmed by recombinant protein). A dilution of 1: 300 to 1: 2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications. |
| Storage Instruction: | Maintain the lyophilised/reconstituted antibodies frozen at-20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, Glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles. |
| Gene Symbol: | CACNA2D2 |
| Gene ID: | 9254 |
| Uniprot ID: | CA2D2_HUMAN |
| Immunogen Region: | 560-610 aa |
| Specificity: | Specific for CACNA2D2. |
| Immunogen: | A synthetic peptide from aa region 560-610 of human CACNA2D2 conjugated to blue carrier protein was used as the antigen. The antigen shares 95% identity with the corresponding sequences in mouse and rat. |
| Post Translational Modifications | May be proteolytically processed into subunits alpha-2-2 and delta-2 that are disulfide-linked. It is however unclear whether such cleavage really takes place in vivo and has a functional role. |
| Function | The alpha-2/delta subunit of voltage-dependent calcium channels regulates calcium current density and activation/inactivation kinetics of the calcium channel. Acts as a regulatory subunit for P/Q-type calcium channel (CACNA1A), N-type (CACNA1B), L-type (CACNA1C OR CACNA1D) and possibly T-type (CACNA1G). Overexpression induces apoptosis. |
| Protein Name | Voltage-Dependent Calcium Channel Subunit Alpha-2/Delta-2Voltage-Gated Calcium Channel Subunit Alpha-2/Delta-2 Cleaved Into - Voltage-Dependent Calcium Channel Subunit Alpha-2-2 - Voltage-Dependent Calcium Channel Subunit Delta-2 |
| Database Links | Reactome: R-HSA-112308Reactome: R-HSA-400042Reactome: R-HSA-422356Reactome: R-HSA-5576892Reactome: R-HSA-5576893Reactome: R-HSA-9662360 |
| Cellular Localisation | MembraneSingle-Pass Type I Membrane ProteinColocalizes With Cacna1a In Lipid Raft Fractions |
| Alternative Antibody Names | Anti-Voltage-Dependent Calcium Channel Subunit Alpha-2/Delta-2 antibodyAnti-Voltage-Gated Calcium Channel Subunit Alpha-2/Delta-2 Cleaved Into - Voltage-Dependent Calcium Channel Subunit Alpha-2-2 - Voltage-Dependent Calcium Channel Subunit Delta-2 antibodyAnti-CACNA2D2 antibodyAnti-KIAA0558 antibody |
Information sourced from Uniprot.org
