Western blot analysis of 1) 293T, 2) Mouse Brain Tissue, 3) Rat Brain Tissue with CaV α2δ2 Rabbit pAb diluted at 1:2,000.

Anti-CACNA2D2 antibody (540-620 aa) (STJ197411)

SKU:
STJ197411
£48.00 - £252.00
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Host: Rabbit
Applications: WB/IHC/IF
Reactivity: Human/Rat/Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Rabbit polyclonal antibody anti-Voltage-dependent calcium channel subunit alpha-2/delta-2 (540-620 aa) is suitable for use in Western Blot, Immunohistochemistry and Immunofluorescence research applications.
Clonality : Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: WB 1:500-1:2000
IHC 1:100-1:300
ELISA 1:40000
IF 1:50-200
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: CACNA2D2
Gene ID: 9254
Uniprot ID: CA2D2_HUMAN
Immunogen Region: 540-620 aa
Specificity: The antibody detects endogenous CaV Alpha 2 Delta 2 protein
Immunogen: Synthetic peptide derived from CaV Alpha 2 Delta 2 at the amino acid range 540-620
Post Translational Modifications May be proteolytically processed into subunits alpha-2-2 and delta-2 that are disulfide-linked. It is however unclear whether such cleavage really takes place in vivo and has a functional role.
Function The alpha-2/delta subunit of voltage-dependent calcium channels regulates calcium current density and activation/inactivation kinetics of the calcium channel. Acts as a regulatory subunit for P/Q-type calcium channel (CACNA1A), N-type (CACNA1B), L-type (CACNA1C OR CACNA1D) and possibly T-type (CACNA1G). Overexpression induces apoptosis.
Protein Name Voltage-Dependent Calcium Channel Subunit Alpha-2/Delta-2
Voltage-Gated Calcium Channel Subunit Alpha-2/Delta-2 Cleaved Into - Voltage-Dependent Calcium Channel Subunit Alpha-2-2 - Voltage-Dependent Calcium Channel Subunit Delta-2
Database Links Reactome: R-HSA-112308
Reactome: R-HSA-400042
Reactome: R-HSA-422356
Reactome: R-HSA-5576892
Reactome: R-HSA-5576893
Reactome: R-HSA-9662360
Cellular Localisation Membrane
Single-Pass Type I Membrane Protein
Colocalizes With Cacna1a In Lipid Raft Fractions
Alternative Antibody Names Anti-Voltage-Dependent Calcium Channel Subunit Alpha-2/Delta-2 antibody
Anti-Voltage-Gated Calcium Channel Subunit Alpha-2/Delta-2 Cleaved Into - Voltage-Dependent Calcium Channel Subunit Alpha-2-2 - Voltage-Dependent Calcium Channel Subunit Delta-2 antibody
Anti-CACNA2D2 antibody
Anti-KIAA0558 antibody

Information sourced from Uniprot.org

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