| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | C8B |
| Gene ID: | 732 |
| Uniprot ID: | CO8B_HUMAN |
| Immunogen Region: | 55-350 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 55-350 of human C8B (NP_000057.2). |
| Immunogen Sequence: | SVDVTLMPIDCELSSWSSWT TCDPCQKKRYRYAYLLQPSQ FHGEPCNFSDKEVEDCVTNR PCRSQVRCEGFVCAQTGRCV NRRLLCNGDNDCGDQSDEAN CRRIYKKCQHEMDQYWGIGS LASGINLFTNSFEGPVLDHR YYAGGCSPHYILNTRFRKPY NVESYTPQTQGKYEFILKEY ESYSDFERNVTEKMASKSGF SFGFKIPGIFELGISSQSDR GKHYIRRTKRFSHTKSVFL |
| Post Translational Modifications | N-glycosylated.contains one or two bound glycans. Not O-glycosylated. |
| Function | Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells. |
| Protein Name | Complement Component C8 Beta ChainComplement Component 8 Subunit Beta |
| Database Links | Reactome: R-HSA-166665Reactome: R-HSA-977606 |
| Cellular Localisation | Secreted |
| Alternative Antibody Names | Anti-Complement Component C8 Beta Chain antibodyAnti-Complement Component 8 Subunit Beta antibodyAnti-C8B antibody |
Information sourced from Uniprot.org