| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-C6orf25 (18-142) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:200-1:1000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
MPIG6B |
| Gene ID: |
80739 |
| Uniprot ID: |
G6B_HUMAN |
| Immunogen Region: |
18-142 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 18-142 of human C6orf25 (NP_612121.1). |
| Immunogen Sequence: |
NPGASLDGRPGDRVNLSCGG VSHPIRWVWAPSFPACKGLS KGRRPILWASSSGTPTVPPL QPFVGRLRSLDSGIRRLELL LSAGDSGTFFCKGRHEDESR TVLHVLGDRTYCKAPGPTHG SVYPQ |
| Tissue Specificity | Expressed in platelets. Expressed in a restricted set of hematopoietic cell lines including the erythroleukemia cell line K-562 and the T-cell leukemia cell lines MOLT-4 and Jurkat. Not detected in the monocyte-like cell line U-937, the B-cell-like cell line Raji, the fibroblast cell lines TK and HeLa, or the natural killer cell lines NKL, NK 62 and YT. |
| Post Translational Modifications | All isoforms are N-glycosylated. Isoform E is O-glycosylated. Phosphorylated. |
| Function | Inhibitory receptor that acts as a critical regulator of hematopoietic lineage differentiation, megakaryocyte function and platelet production. Inhibits platelet aggregation and activation by agonists such as ADP and collagen-related peptide. This regulation of megakaryocate function as well as platelet production ann activation is done through the inhibition (via the 2 ITIM motifs) of the receptors CLEC1B and GP6:FcRgamma signaling. Appears to operate in a calcium-independent manner. Isoform B, displayed in this entry, is the only isoform to contain both a transmembrane region and 2 immunoreceptor tyrosine-based inhibitor motifs (ITIMs) and, thus, the only one which probably has a role of inhibitory receptor. Isoform A may be the activating counterpart of isoform B. |
| Protein Name | Megakaryocyte And Platelet Inhibitory Receptor G6bProtein G6b |
| Database Links | Reactome: R-HSA-114604 |
| Cellular Localisation | Isoform E: Endoplasmic ReticulumGolgi ApparatusIsoform D: Endoplasmic ReticulumIsoform B: Cell MembraneSingle-Pass Type I Membrane ProteinIsoform A: Cell Membrane |
| Alternative Antibody Names | Anti-Megakaryocyte And Platelet Inhibitory Receptor G6b antibodyAnti-Protein G6b antibodyAnti-MPIG6B antibodyAnti-C6orf25 antibodyAnti-G6B antibodyAnti-G6B-B antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
