| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Phospholipid transfer protein C2CD2L is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
WB 1:500-2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
C2CD2L |
| Gene ID: |
9854 |
| Uniprot ID: |
C2C2L_HUMAN |
| Specificity: |
This antibody detects endogenous levels of TMEM24 at Human, Mouse |
| Immunogen: |
Synthesized peptide derived from human TMEM24 |
| Function | Lipid-binding protein that transports phosphatidylinositol, the precursor of phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2), from its site of synthesis in the endoplasmic reticulum to the cell membrane. It thereby maintains the pool of cell membrane phosphoinositides, which are degraded during phospholipase C (PLC) signaling. Plays a key role in the coordination of Ca(2+) and phosphoinositide signaling: localizes to sites of contact between the endoplasmic reticulum and the cell membrane, where it tethers the two bilayers. In response to elevation of cytosolic Ca(2+), it is phosphorylated at its C-terminus and dissociates from the cell membrane, abolishing phosphatidylinositol transport to the cell membrane. Positively regulates insulin secretion in response to glucose: phosphatidylinositol transfer to the cell membrane allows replenishment of PI(4,5)P2 pools and calcium channel opening, priming a new population of insulin granules. |
| Protein Name | Phospholipid Transfer Protein C2cd2lC2 Domain-Containing Protein 2-LikeC2cd2-LikeTransmembrane Protein 24 |
| Cellular Localisation | Endoplasmic Reticulum MembraneSingle-Pass Membrane ProteinCell MembranePeripheral Membrane ProteinLocalizes To Sites Of Contact Between The Endoplasmic Reticulum And The Cell MembraneEmbedded Into The Endoplasmic Reticulum Membrane Via Its N-Terminal Transmembrane Domain And Associates With Cell Membrane Via Its C-TerminusIn Response To Elevation Of Cytosolic Ca(2+)It Is Phosphorylated At Its C-Terminus And Dissociates From The Cell Membrane And Localizes To The Reticular Endoplasmic ReticulumReassociates With Cell Membrane Upon Dephosphorylation |
| Alternative Antibody Names | Anti-Phospholipid Transfer Protein C2cd2l antibodyAnti-C2 Domain-Containing Protein 2-Like antibodyAnti-C2cd2-Like antibodyAnti-Transmembrane Protein 24 antibodyAnti-C2CD2L antibodyAnti-KIAA0285 antibodyAnti-TMEM24 antibodyAnti-DLNB23 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
