| Function | Lipid-binding protein that transports phosphatidylinositol, the precursor of phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2), from its site of synthesis in the endoplasmic reticulum to the cell membrane. It thereby maintains the pool of cell membrane phosphoinositides, which are degraded during phospholipase C (PLC) signaling. Plays a key role in the coordination of Ca(2+) and phosphoinositide signaling: localizes to sites of contact between the endoplasmic reticulum and the cell membrane, where it tethers the two bilayers. In response to elevation of cytosolic Ca(2+), it is phosphorylated at its C-terminus and dissociates from the cell membrane, abolishing phosphatidylinositol transport to the cell membrane. Positively regulates insulin secretion in response to glucose: phosphatidylinositol transfer to the cell membrane allows replenishment of PI(4,5)P2 pools and calcium channel opening, priming a new population of insulin granules. |
| Protein Name | Phospholipid Transfer Protein C2cd2lC2 Domain-Containing Protein 2-LikeC2cd2-LikeTransmembrane Protein 24 |
| Cellular Localisation | Endoplasmic Reticulum MembraneSingle-Pass Membrane ProteinCell MembranePeripheral Membrane ProteinLocalizes To Sites Of Contact Between The Endoplasmic Reticulum And The Cell MembraneEmbedded Into The Endoplasmic Reticulum Membrane Via Its N-Terminal Transmembrane Domain And Associates With Cell Membrane Via Its C-TerminusIn Response To Elevation Of Cytosolic Ca(2+)It Is Phosphorylated At Its C-Terminus And Dissociates From The Cell Membrane And Localizes To The Reticular Endoplasmic ReticulumReassociates With Cell Membrane Upon Dephosphorylation |
| Alternative Antibody Names | Anti-Phospholipid Transfer Protein C2cd2l antibodyAnti-C2 Domain-Containing Protein 2-Like antibodyAnti-C2cd2-Like antibodyAnti-Transmembrane Protein 24 antibodyAnti-C2CD2L antibodyAnti-KIAA0285 antibodyAnti-TMEM24 antibodyAnti-DLNB23 antibody |
Information sourced from Uniprot.org
