| Host: | Rabbit |
| Applications: | WB/IF/ICC/ELISA |
| Reactivity: | Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | Spo16 |
| Gene ID: | 76421 |
| Uniprot ID: | SPO16_MOUSE |
| Immunogen Region: | 47-173 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 47-173 of mouse C1orf146 (NP_877422.2). |
| Immunogen Sequence: | GSIVFSLSGVAFLLMDAKEC MTSAEEIFVTKIEKFINIHQ NSFLVLFAPLHGPEEWSLMF RIHQRFLGSNLRILPVHNTV NALDLMCTIAKTTSKPHIDS ICYRMITTKAYIIEQSPVWR TLQKIKL |
| Tissue Specificity | Testis (at protein level). |
| Function | Plays a key role in reinforcing the integrity of the central element of the synaptonemal complex (SC) thereby stabilizing SC, ensuring progression of meiotic prophase I in male and female germ cells. Promotes homologous recombination and crossing-over in meiotic prophase I via its association with SHOC1. Required for the localization of TEX11 and MSH4 to recombination intermediates. |
| Protein Name | Protein Spo16 HomologSynaptonemal Complex Reinforcing Element |
| Cellular Localisation | Chromosome |
| Alternative Antibody Names | Anti-Protein Spo16 Homolog antibodyAnti-Synaptonemal Complex Reinforcing Element antibodyAnti-Spo16 antibodyAnti-Scre antibody |
Information sourced from Uniprot.org