| Tissue Specificity | Widely expressed. Expressed at high level in heart and skeletal muscle. Expressed at intermediate level in liver, pancreas, fetal brain and fetal lung. Weakly expressed in adult brain, adult lung, placenta, fetal liver and fetal kidney. Overexpressed in many brain tumors. |
| Function | RNA-binding protein involved in modulation of mRNA transcription by Polymerase II. Component of the tRNA-splicing ligase complex and is required for tRNA ligation. May be required for RNA transport. (Microbial infection) In case of infection by influenza virus A (IVA), is involved in viral replication. |
| Protein Name | Rna Transcription - Translation And Transport Factor ProteinCle7 HomologCleHcle |
| Database Links | Reactome: R-HSA-6784531 |
| Cellular Localisation | NucleusCytoplasmCytosolPerinuclear RegionCytoskeletonMicrotubule Organizing CenterCentrosomeMay Localize At The Centrosome During MitosisShuttles Between The Cytosol And The Nucleus: Enters Into The Nucleus In Case Of Active Transcription While It Accumulates In Cytosol When Transcription Level Is Low(Microbial Infection) Following Influenza A Virus (Iav) InfectionIncluded In Influenza A Virions Via Its Association With Packaged Viral Ribonucleoproteins (Vrnp) In The Nucleus And Cytoplasm |
| Alternative Antibody Names | Anti-Rna Transcription - Translation And Transport Factor Protein antibodyAnti-Cle7 Homolog antibodyAnti-Cle antibodyAnti-Hcle antibodyAnti-RTRAF antibodyAnti-C14orf166 antibodyAnti-CGI-99 antibody |
Information sourced from Uniprot.org
