| Host: | Rabbit |
| Applications: | IHC-P/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | IHC-P:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | MYG1 |
| Gene ID: | 60314 |
| Uniprot ID: | MYG1_HUMAN |
| Immunogen Region: | 48-376 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 48-376 of human C12orf10 (NP_067653.3). |
| Immunogen Sequence: | GTHNGTFHCDEALACALLRL LPEYRDAEIVRTRDPEKLAS CDIVVDVGGEYDPRRHRYDH HQRSFTETMSSLSPGKPWQT KLSSAGLIYLHFGHKLLAQL LGTSEEDSMVGTLYDKMYEN FVEEVDAVDNGISQWAEGEP RYALTTTLSARVARLNPTWN HPDQDTEAGFKRAMDLVQEE FLQRLDFYQHSWLPARALVE EALAQRFQVDPSGEIVELAK GACPWKEHLYHLESGLSPP |
| Tissue Specificity | Ubiquitously expressed, with highest levels in testis. |
| Function | 3'-5' RNA exonuclease which cleaves in situ on specific transcripts in both nucleus and mitochondrion. Involved in regulating spatially segregated organellar RNA processing, acts as a coordinator of nucleo-mitochondrial crosstalk. In nucleolus, processes pre-ribosomal RNA involved in ribosome assembly and alters cytoplasmic translation. In mitochondrial matrix, processes 3'-termini of the mito-ribosomal and messenger RNAs and controls translation of mitochondrial proteins (Probable). |
| Protein Name | Myg1 Exonuclease |
| Cellular Localisation | NucleusNucleoplasmMitochondrion MatrixNucleolus |
| Alternative Antibody Names | Anti-Myg1 Exonuclease antibodyAnti-MYG1 antibodyAnti-C12orf10 antibody |
Information sourced from Uniprot.org