||WB, IHC-P, ELISA
||Rabbit polyclonal anti-c-FLIP antibody is suitable for use in Western Blot, Immunohistochemistry and ELISA.
||FOR RESEARCH USE ONLY (RUO).
||Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
||The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using a epitope-specific immunogen.
||Store at-20°C, and avoid repeat freeze-thaw cycles.
||WB 1:500-1:2000IHC 1:100-1:300ELISA 1:20000
||c-FLIP polyclonal antibody detects endogenous levels of c-FLIP protein.
||Synthesized peptide derived from human c-FLIP
||150-230 aa, Internal
| Post Translational Modifications || Proteolytically processed by CASP8 generating subunit p43 and p12. |
| Function || Apoptosis regulator protein which may function as a crucial link between cell survival and cell death pathways in mammalian cells. Acts as an inhibitor of TNFRSF6 mediated apoptosis. A proteolytic fragment (p43) is likely retained in the death-inducing signaling complex (DISC) thereby blocking further recruitment and processing of caspase-8 at the complex. Full length and shorter isoforms have been shown either to induce apoptosis or to reduce TNFRSF-triggered apoptosis. Lacks enzymatic (caspase) activity. |
| Protein Name || Casp8 And Fadd-Like Apoptosis RegulatorCaspase HomologCashCaspase-Eight-Related ProteinCasperCaspase-Like Apoptosis Regulatory ProteinClarpCellular Flice-Like Inhibitory ProteinC-FlipFadd-Like Antiapoptotic Molecule 1Flame-1Inhibitor Of FliceI-FliceMach-Related Inducer Of ToxicityMritUsurpin Cleaved Into - Casp8 And Fadd-Like Apoptosis Regulator Subunit P43 - Casp8 And Fadd-Like Apoptosis Regulator Subunit P12 |
| Database Links || Reactome: R-HSA-3371378 O15519-1Reactome: R-HSA-5213460Reactome: R-HSA-5218900Reactome: R-HSA-5357905 O15519-1Reactome: R-HSA-69416 O15519-2Reactome: R-HSA-75158 |
| Alternative Antibody Names || Anti-Casp8 And Fadd-Like Apoptosis Regulator antibodyAnti-Caspase Homolog antibodyAnti-Cash antibodyAnti-Caspase-Eight-Related Protein antibodyAnti-Casper antibodyAnti-Caspase-Like Apoptosis Regulatory Protein antibodyAnti-Clarp antibodyAnti-Cellular Flice-Like Inhibitory Protein antibodyAnti-C-Flip antibodyAnti-Fadd-Like Antiapoptotic Molecule 1 antibodyAnti-Flame-1 antibodyAnti-Inhibitor Of Flice antibodyAnti-I-Flice antibodyAnti-Mach-Related Inducer Of Toxicity antibodyAnti-Mrit antibodyAnti-Usurpin Cleaved Into - Casp8 And Fadd-Like Apoptosis Regulator Subunit P43 - Casp8 And Fadd-Like Apoptosis Regulator Subunit P12 antibodyAnti-CFLAR antibodyAnti-CASH antibodyAnti-CASP8AP1 antibodyAnti-CLARP antibodyAnti-MRIT antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance