Anti-c-FLIP antibody (STJ92242)

SKU:
STJ92242

Current Stock:
Host: Rabbit
Applications: WB, IHC-P, ELISA
Reactivity: Human
Short Description: Rabbit polyclonal anti-c-FLIP antibody is suitable for use in Western Blot, Immunohistochemistry and ELISA.
Note: FOR RESEARCH USE ONLY (RUO).
Clonality: Polyclonal
Conjugation: Unconjugated
Formulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using a epitope-specific immunogen.
Storage Instruction: Store at-20°C, and avoid repeat freeze-thaw cycles.
Concentration: 1 mg/ml
Isotype: IgG
Dilution Range: WB 1:500-1:2000
IHC 1:100-1:300
ELISA 1:20000
Specificity: c-FLIP polyclonal antibody detects endogenous levels of c-FLIP protein.
Uniprot ID: CFLAR_HUMAN
Gene ID: 8837
Gene Symbol: CFLAR
Immunogen: Synthesized peptide derived from human c-FLIP
Immunogen Region: 150-230 aa, Internal
Post Translational Modifications Proteolytically processed by CASP8 generating subunit p43 and p12.
Function Apoptosis regulator protein which may function as a crucial link between cell survival and cell death pathways in mammalian cells. Acts as an inhibitor of TNFRSF6 mediated apoptosis. A proteolytic fragment (p43) is likely retained in the death-inducing signaling complex (DISC) thereby blocking further recruitment and processing of caspase-8 at the complex. Full length and shorter isoforms have been shown either to induce apoptosis or to reduce TNFRSF-triggered apoptosis. Lacks enzymatic (caspase) activity.
Protein Name Casp8 And Fadd-Like Apoptosis Regulator
Caspase Homolog
Cash
Caspase-Eight-Related Protein
Casper
Caspase-Like Apoptosis Regulatory Protein
Clarp
Cellular Flice-Like Inhibitory Protein
C-Flip
Fadd-Like Antiapoptotic Molecule 1
Flame-1
Inhibitor Of Flice
I-Flice
Mach-Related Inducer Of Toxicity
Mrit
Usurpin Cleaved Into - Casp8 And Fadd-Like Apoptosis Regulator Subunit P43 - Casp8 And Fadd-Like Apoptosis Regulator Subunit P12
Database Links Reactome: R-HSA-3371378 O15519-1
Reactome: R-HSA-5213460
Reactome: R-HSA-5218900
Reactome: R-HSA-5357905 O15519-1
Reactome: R-HSA-69416 O15519-2
Reactome: R-HSA-75158
Alternative Antibody Names Anti-Casp8 And Fadd-Like Apoptosis Regulator antibody
Anti-Caspase Homolog antibody
Anti-Cash antibody
Anti-Caspase-Eight-Related Protein antibody
Anti-Casper antibody
Anti-Caspase-Like Apoptosis Regulatory Protein antibody
Anti-Clarp antibody
Anti-Cellular Flice-Like Inhibitory Protein antibody
Anti-C-Flip antibody
Anti-Fadd-Like Antiapoptotic Molecule 1 antibody
Anti-Flame-1 antibody
Anti-Inhibitor Of Flice antibody
Anti-I-Flice antibody
Anti-Mach-Related Inducer Of Toxicity antibody
Anti-Mrit antibody
Anti-Usurpin Cleaved Into - Casp8 And Fadd-Like Apoptosis Regulator Subunit P43 - Casp8 And Fadd-Like Apoptosis Regulator Subunit P12 antibody
Anti-CFLAR antibody
Anti-CASH antibody
Anti-CASP8AP1 antibody
Anti-CLARP antibody
Anti-MRIT antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance