Anti-BUD23 antibody (144-194 aa) (STJ193867)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from the human WBS22 at the amino acid range 144-194
General Information
| Short Description | Rabbit polyclonal anti-Probable 18S rRNA-methyltransferase (144-194 aa) for use in WB in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | BUD23 |
| Gene ID | 114049 |
| Uniprot ID | BUD23_HUMAN |
| Immunogen | Synthesized peptide derived from the human WBS22 at the amino acid range 144-194 |
| Immunogen Region | 144-194 aa |
| Specificity | This antibody detects endogenous levels of WBS22 at Human/Mouse |
Additional Info
| Post Translational Modifications | May be ubiquitinated and targeted to degradation in response to pro-inflammatory cytokine signaling. |
| Function | S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the N(7) position of a guanine in 18S rRNA. Requires the methyltransferase adapter protein TRM112 for full rRNA methyltransferase activity. Involved in the pre-rRNA processing steps leading to small-subunit rRNA production independently of its RNA-modifying catalytic activity. Important for biogenesis end export of the 40S ribosomal subunit independent on its methyltransferase activity. Locus-specific steroid receptor coactivator. Potentiates transactivation by glucocorticoid (NR3C1), mineralocorticoid (NR3C2), androgen (AR) and progesterone (PGR) receptors. Required for the maintenance of open chromatin at the TSC22D3/GILZ locus to facilitate NR3C1 loading on the response elements. Required for maintenance of dimethylation on histone H3 'Lys-79' (H3K79me2), although direct histone methyltransferase activity is not observed in vitro. |
| Protein Name | 18s RrnaGuanine-N(7-MethyltransferaseBud Site Selection Protein 23 HomologMetastasis-Related Methyltransferase 1Williams-Beuren Syndrome Chromosomal Region 22 ProteinRrna Methyltransferase And Ribosome Maturation Factor |
| Database Links | Reactome: R-HSA-6790901Reactome: R-HSA-6791226 |
| Cellular Localisation | NucleusNucleoplasmCytoplasmPerinuclear RegionLocalized Diffusely Throughout The Nucleus And The CytoplasmLocalizes To A Polarized Perinuclear StructureOverlapping Partially With The Golgi And LysosomesLocalization Is Not Affected By Glucocorticoid Treatment |
| Alternative Antibody Names | Anti-18s Rrna antibodyAnti-Guanine-N(7-Methyltransferase antibodyAnti-Bud Site Selection Protein 23 Homolog antibodyAnti-Metastasis-Related Methyltransferase 1 antibodyAnti-Williams-Beuren Syndrome Chromosomal Region 22 Protein antibodyAnti-Rrna Methyltransferase And Ribosome Maturation Factor antibodyAnti-BUD23 antibodyAnti-MERM1 antibodyAnti-WBSCR22 antibodyAnti-HUSSY-03 antibodyAnti-PP3381 antibody |
Information sourced from Uniprot.org