Anti-BPI antibody (248-487) (STJ27291)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal BPI (248-487) antibody for use in WB and ELISA in human and mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | BPI |
| Gene ID | 671 |
| Uniprot ID | BPI_HUMAN |
| Immunogen Region | 248-487 |
| Immunogen Sequence | AETLDVQMKGEFYSENHHNP PPFAPPVMEFPAAHDRMVYL GLSDYFFNTAGLVYQEAGVL KMTLRDDMIPKESKFRLTTK FFGTFLPEVAKKFPNMKIQI HVSASTPPHLSVQPTGLTFY PAVDVQAFAVLPNSSLASLF LIGMHTTGSMEVSAESNRLV GELKLDRLLLELKHSNIGPF PVELLQDIMNYIVPILVLPR VNEKLQKGFPLPTPARVQLY NVVLQPHQNFLLFGADVVY |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 248-487 of human BPI (NP_001716.2). |
Additional Info
| Tissue Specificity | Restricted to cells of the myeloid series. |
| Function | The cytotoxic action of BPI is limited to many species of Gram-negative bacteria.this specificity may be explained by a strong affinity of the very basic N-terminal half for the negatively charged lipopolysaccharides that are unique to the Gram-negative bacterial outer envelope. Has antibacterial activity against the Gram-negative bacterium P.aeruginosa, this activity is inhibited by LPS from P.aeruginosa. |
| Protein Name | Bactericidal Permeability-Increasing ProteinBpiCap 57 |
| Database Links | Reactome: R-HSA-166016Reactome: R-HSA-6798695Reactome: R-HSA-6803157 |
| Cellular Localisation | SecretedCytoplasmic Granule MembraneMembrane-Associated In Polymorphonuclear Leukocytes (Pmn) Granules |
| Alternative Antibody Names | Anti-Bactericidal Permeability-Increasing Protein antibodyAnti-Bpi antibodyAnti-Cap 57 antibodyAnti-BPI antibody |
Information sourced from Uniprot.org