| Host: |
Goat |
| Applications: |
Pep-ELISA/WB |
| Reactivity: |
Human/Dog |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Goat polyclonal antibody anti-BMPR1A (Internal) is suitable for use in ELISA and Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Purification: |
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Concentration: |
0.5 mg/mL |
| Dilution Range: |
Peptide ELISA: antibody detection limit dilution 1:16000.WB: Approx 60kDa band observed in lysates of cell lines HeLa and HepG2 (calculated MW of 60.2kDa according to NP_004320.2). Recommended concentration: 1-3µg/ml.An additional band of 20kDa |
| Storage Instruction: |
Store at-20°C on receipt and minimise freeze-thaw cycles. |
| Gene Symbol: |
BMPR1A |
| Gene ID: |
657 |
| Uniprot ID: |
BMR1A_HUMAN |
| Immunogen Region: |
Internal |
| Accession Number: |
NP_004320.2 |
| Immunogen Sequence: |
KSDSDQKKSEN |
| Post Translational Modifications | Glycosylated. |
| Function | On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for BMP2, BMP4, GDF5 and GDF6. Positively regulates chondrocyte differentiation through GDF5 interaction. Mediates induction of adipogenesis by GDF6. May promote the expression of HAMP, potentially via its interaction with BMP2. |
| Protein Name | Bone Morphogenetic Protein Receptor Type-1aBmp Type-1a ReceptorBmpr-1aActivin Receptor-Like Kinase 3Alk-3Serine/Threonine-Protein Kinase Receptor R5Skr5Cd Antigen Cd292 |
| Database Links | Reactome: R-HSA-201451 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane ProteinCell Surface |
| Alternative Antibody Names | Anti-Bone Morphogenetic Protein Receptor Type-1a antibodyAnti-Bmp Type-1a Receptor antibodyAnti-Bmpr-1a antibodyAnti-Activin Receptor-Like Kinase 3 antibodyAnti-Alk-3 antibodyAnti-Serine/Threonine-Protein Kinase Receptor R5 antibodyAnti-Skr5 antibodyAnti-Cd Antigen Cd292 antibodyAnti-BMPR1A antibodyAnti-ACVRLK3 antibodyAnti-ALK3 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
