| Host: | Rabbit |
| Applications: | ELISA/IHC/IP/WB |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-BMP1 (1-50) is suitable for use in ELISA, Immunohistochemistry, Immunoprecipitation and Western Blot research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Contains Tris, HCl/Glycine buffer pH 7.4-7.8, 30% Glycerol and 0.5% BSA, along with cryo-protective agents, Hepes, and long-term preservatives (0.02% Sodium Azide). |
| Purification: | Affinity Purified |
| Concentration: | 0.50-0.56 µg/µl |
| Dilution Range: | WB: 1:500 DB: 1:2, 000 ELISA: 1:2, 000 IP: 1:200 IHC: 1:50-1:150 |
| Storage Instruction: | Store at-20°C for long term storage. Avoid freeze-thaw cycles. |
| Gene Symbol: | BMP1 |
| Gene ID: | 649 |
| Uniprot ID: | BMP1_HUMAN |
| Immunogen Region: | 1-50 |
| Immunogen: | Synthetic peptide taken within amino acid region 1-50 on human BMP1 protein. |
| Tissue Specificity | Ubiquitous. |
| Post Translational Modifications | Proteolytically activated in the trans-Golgi network by furin-like/paired basic proprotein convertases, cleavage is not required for secretion. |
| Function | Metalloprotease that plays key roles in regulating the formation of the extracellular matrix (ECM) via processing of various precursor proteins into mature functional enzymes or structural proteins. Thereby participates in several developmental and physiological processes such as cartilage and bone formation, muscle growth and homeostasis, wound healing and tissue repair. Roles in ECM formation include cleavage of the C-terminal propeptides from procollagens such as procollagen I, II and III or the proteolytic activation of the enzyme lysyl oxidase LOX, necessary to formation of covalent cross-links in collagen and elastic fibers. Additional substrates include matricellular thrombospondin-1/THBS1 whose cleavage leads to cell adhesion disruption and TGF-beta activation. Isoform BMP1-3: Plays an important role in bone repair by acting as a coactivator of BMP7. |
| Protein Name | Bone Morphogenetic Protein 1 Bmp-1 Mammalian Tolloid Protein Mtld Procollagen C-Proteinase Pcp |
| Database Links | Reactome: R-HSA-1474228 Reactome: R-HSA-1650814 Reactome: R-HSA-2214320 Reactome: R-HSA-2243919 Reactome: R-HSA-8963896 P13497-3 |
| Cellular Localisation | Golgi Apparatus Trans-Golgi Network Secreted Extracellular Space Extracellular Matrix Co-Localizes With Postn In The Golgi Isoform Bmp1-3: Secreted |
| Alternative Antibody Names | Anti-Bone Morphogenetic Protein 1 antibody Anti-Bmp-1 antibody Anti-Mammalian Tolloid Protein antibody Anti-Mtld antibody Anti-Procollagen C-Proteinase antibody Anti-Pcp antibody Anti-BMP1 antibody Anti-PCOLC antibody |
Information sourced from Uniprot.org