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![Anti-BCL10 antibody [EBS-T-001] (STJ16101062)](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/124x110/products/149778/302526/STJ16101062_2__22940.1646940686.jpg?c=1 "Anti-BCL10 antibody [EBS-T-001] (STJ16101062)")
![Anti-BCL10 antibody [EBS-T-001] (STJ16101062)](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/1280x1280/products/149778/302525/STJ16101062_1__54433.1646940686.jpg?c=1 "Anti-BCL10 antibody [EBS-T-001] (STJ16101062)")
| Host: | Mouse |
| Applications: | WB/IHC |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Mouse monoclonal antibody anti-BCL10 is suitable for use in Western Blot and Immunohistochemistry research applications. |
| Clonality : | Monoclonal |
| Clone ID : | EBS-T-001 |
| Conjugation: | Unconjugated |
| Isotype: | IgG1k |
| Formulation: | PBS with 0.02% Sodium Azide. |
| Purification: | Affinity purified from tissue culture. |
| Concentration: | Can be provided as 100 µg/mL, 500 µg/mL or 1mg/mL. |
| Dilution Range: | Immunoblotting (1-2 µg/ml). Immunohistology (formalin-fixed: 1-2 µg/ml for 30 min at RT; requires boiling tissue sections in 10mM citrate buffer, pH 6, 0, for 10-20 min followed by cooling at RT for 20 minutes). |
| Storage Instruction: | Store for up to 1 year at 2-8°C upon receipt. |
| Gene Symbol: | BCL10 |
| Gene ID: | 8915 |
| Uniprot ID: | BCL10_HUMAN |
| Immunogen: | A BALB/c mouse was immunized with human BCL10 recombinant protein (aa122-168). Fusion partner: SP2/0. |
| Tissue Specificity | Ubiquitous. |
| Post Translational Modifications | Phosphorylated. Phosphorylation results in dissociation from TRAF2 and binding to BIRC2/c-IAP2. Phosphorylated by IKBKB/IKKB. Ubiquitinated via both 'Lys-63'-linked and linear ('Met-1'-linked) polyubiquitin chains in response to T-cell receptor (TCR) activation. Ubiquitination is recognized by IKBKG/NEMO, the regulatory subunit of I-kappa-B kinase (IKK), and is required for TCR-induced NF-kappa-B activation. Linear ubiquitination at Lys-17, Lys-31 and Lys-63 is mediated by RNF31/HOIP.linear ubiquitination is recognized with much higher affinity than 'Lys-63'-linked ubiquitin by IKBKG/NEMO. CARD11 is required for linear ubiquitination by HOIP by promoting the targeting of BCL10 to RNF31/HOIP. Proteolytically cleaved by MALT1.required for T-cell activation. |
| Function | Plays a key role in both adaptive and innate immune signaling by bridging CARD domain-containing proteins to immune activation. Acts by channeling adaptive and innate immune signaling downstream of CARD domain-containing proteins CARD9, CARD11 and CARD14 to activate NF-kappa-B and MAP kinase p38 (MAPK11, MAPK12, MAPK13 and/or MAPK14) pathways which stimulate expression of genes encoding pro-inflammatory cytokines and chemokines. Recruited by activated CARD domain-containing proteins: homooligomerized CARD domain-containing proteins form a nucleating helical template that recruits BCL10 via CARD-CARD interaction, thereby promoting polymerization of BCL10, subsequent recruitment of MALT1 and formation of a CBM complex. This leads to activation of NF-kappa-B and MAP kinase p38 (MAPK11, MAPK12, MAPK13 and/or MAPK14) pathways which stimulate expression of genes encoding pro-inflammatory cytokines and chemokines. Activated by CARD9 downstream of C-type lectin receptors.CARD9-mediated signals are essential for antifungal immunity. Activated by CARD11 downstream of T-cell receptor (TCR) and B-cell receptor (BCR). Promotes apoptosis, pro-caspase-9 maturation and activation of NF-kappa-B via NIK and IKK. |
| Protein Name | B-Cell Lymphoma/Leukemia 10 B-Cell Cll/Lymphoma 10 Bcl-10 Card-Containing Molecule Enhancing Nf-Kappa-B Card-Like Apoptotic Protein Hclap Ced-3/Ich-1 Prodomain Homologous E10-Like Regulator Ciper Cellular Homolog Of Vcarmen Ccarmen Cellular-E10 C-E10 Mammalian Card-Containing Adapter Molecule E10 Me10 |
| Database Links | Reactome: R-HSA-1169091 Reactome: R-HSA-202424 Reactome: R-HSA-2871837 Reactome: R-HSA-5607764 Reactome: R-HSA-8866654 |
| Cellular Localisation | Cytoplasm Perinuclear Region Membrane Raft Appears To Have A Perinuclear Compact And Filamentous Pattern Of Expression Also Found In The Nucleus Of Several Types Of Tumor Cells Colocalized With Dpp4 In Membrane Rafts |
| Alternative Antibody Names | Anti-B-Cell Lymphoma/Leukemia 10 antibody Anti-B-Cell Cll/Lymphoma 10 antibody Anti-Bcl-10 antibody Anti-Card-Containing Molecule Enhancing Nf-Kappa-B antibody Anti-Card-Like Apoptotic Protein antibody Anti-Hclap antibody Anti-Ced-3/Ich-1 Prodomain Homologous E10-Like Regulator antibody Anti-Ciper antibody Anti-Cellular Homolog Of Vcarmen antibody Anti-Ccarmen antibody Anti-Cellular-E10 antibody Anti-C-E10 antibody Anti-Mammalian Card-Containing Adapter Molecule E10 antibody Anti-Me10 antibody Anti-BCL10 antibody Anti-CIPER antibody Anti-CLAP antibody |
Information sourced from Uniprot.org