| Short Description : | Rabbit polyclonal BCHE (29-270) antibody for use in WB and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications: | WB/ELISA |
| Host: | Rabbit |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Concentration: | Lot specific |
| Purification: | Affinity purification |
| Dilution Range: | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | BCHE |
| Gene ID: | 590 |
| Uniprot ID: | CHLE_HUMAN |
| Immunogen Region: | 29-270 |
| Immunogen Sequence: | EDDIIIATKNGKVRGMNLTV FGGTVTAFLGIPYAQPPLGR LRFKKPQSLTKWSDIWNATK YANSCCQNIDQSFPGFHGSE MWNPNTDLSEDCLYLNVWIP APKPKNATVLIWIYGGGFQT GTSSLHVYDGKFLARVERVI VVSMNYRVGALGFLALPGNP EAPGNMGLFDQQLALQWVQK NIAAFGGNPKSVTLFGESAG AASVSLHLLSPGSHSLFTRA ILQSGSFNAPWAVTSLYEA |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 29-270 of human Butyrylcholinesterase (NP_000046.1). |
| Tissue Specificity | Detected in blood plasma (at protein level). Present in most cells except erythrocytes. |
| Post Translational Modifications | N-glycosylated. No other PTM detected. The major N-glycan structures are of the complex diantennary type with 1 and 2 N-acetylneuraminic acid molecules (Neu5Ac) making up approximately 33% and 47% of the total N-glycans, respectively. Only low amounts of fucosylated diantennary N-glycans are detected (approximately 2%). Triantennary N-glycans with or without fucose amount to approximately 13%, whereas 5% of the total N-glycans are of the oligomannosidic or hybrid type. |
| Function | Esterase with broad substrate specificity. Contributes to the inactivation of the neurotransmitter acetylcholine. Can degrade neurotoxic organophosphate esters. |
| Protein Name | CholinesteraseAcylcholine AcylhydrolaseButyrylcholine EsteraseCholine Esterase IiPseudocholinesterase |
| Database Links | Reactome: R-HSA-112311Reactome: R-HSA-1483191Reactome: R-HSA-422085Reactome: R-HSA-9749641 |
| Cellular Localisation | Secreted |
| Alternative Antibody Names | Anti-Cholinesterase antibodyAnti-Acylcholine Acylhydrolase antibodyAnti-Butyrylcholine Esterase antibodyAnti-Choline Esterase Ii antibodyAnti-Pseudocholinesterase antibodyAnti-BCHE antibodyAnti-CHE1 antibody |
Information sourced from Uniprot.org
