| Host: |
Rabbit |
| Applications: |
WB/ELISA |
| Reactivity: |
Human/Rat/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-BRCA2 and CDKN1A-interacting protein (60-140 aa) is suitable for use in Western Blot and ELISA research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
WB 1:500-1:2000ELISA 1:5000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
BCCIP |
| Gene ID: |
56647 |
| Uniprot ID: |
BCCIP_HUMAN |
| Immunogen Region: |
60-140 aa |
| Specificity: |
TOK-1 Polyclonal Antibody detects endogenous levels of TOK-1 protein. |
| Immunogen: |
Synthesized peptide derived from TOK-1 at the amino acid range 60-140 |
| Function | During interphase, required for microtubule organizing and anchoring activities. During mitosis, required for the organization and stabilization of the spindle pole. Isoform 2/alpha is particularly important for the regulation of microtubule anchoring, microtubule stability, spindle architecture and spindle orientation, compared to isoform 1/beta. May promote cell cycle arrest by enhancing the inhibition of CDK2 activity by CDKN1A. May be required for repair of DNA damage by homologous recombination in conjunction with BRCA2. May not be involved in non-homologous end joining (NHEJ). |
| Protein Name | Brca2 And Cdkn1a-Interacting ProteinP21- And Cdk-Associated Protein 1Protein Tok-1 |
| Cellular Localisation | NucleusCytoplasmCytoskeletonMicrotubule Organizing CenterCentrosomeCentrioleSpindle PoleColocalizes With Brca2 In Discrete Nuclear FociIn InterphasePreferential Localizes To The Mother CentrioleRecruited To The Spindle Pole Matrix And Centrosome By Microtubules And Dynein/Dynactin ActivityIsoform 1: CytoplasmIsoform 1/Beta Tends To Be Less Abundant AtAnd Less Strongly Associated WithCentrosomes Than Isoform 2/AlphaIsoform 2: CytoplasmIsoform 2/Alpha Tends To Be More Abundant AtAnd More Strongly Associated WithCentrosomes Than Isoform 1/Beta |
| Alternative Antibody Names | Anti-Brca2 And Cdkn1a-Interacting Protein antibodyAnti-P21- And Cdk-Associated Protein 1 antibodyAnti-Protein Tok-1 antibodyAnti-BCCIP antibodyAnti-TOK1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
