Anti-BBS7 antibody (85-135 aa) (STJ195458)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from the human BBS7 at the amino acid range 85-135
General Information
| Short Description | Rabbit polyclonal anti-Bardet-Biedl syndrome 7 protein (85-135 aa) for use in WB in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | BBS7 |
| Gene ID | 55212 |
| Uniprot ID | BBS7_HUMAN |
| Immunogen | Synthesized peptide derived from the human BBS7 at the amino acid range 85-135 |
| Immunogen Region | 85-135 aa |
| Specificity | This antibody detects endogenous levels of BBS7 at Human/Mouse |
Additional Info
| Function | The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function. This ciliogenic function is mediated in part by the Rab8 GDP/GTP exchange factor, which localizes to the basal body and contacts the BBSome. Rab8(GTP) enters the primary cilium and promotes extension of the ciliary membrane. Firstly the BBSome associates with the ciliary membrane and binds to RAB3IP/Rabin8, the guanosyl exchange factor (GEF) for Rab8 and then the Rab8-GTP localizes to the cilium and promotes docking and fusion of carrier vesicles to the base of the ciliary membrane. The BBSome complex, together with the LTZL1, controls SMO ciliary trafficking and contributes to the sonic hedgehog (SHH) pathway regulation. Required for proper BBSome complex assembly and its ciliary localization. |
| Protein Name | Bbsome Complex Member Bbs7Bbs2-Like Protein 1Bardet-Biedl Syndrome 7 Protein |
| Database Links | Reactome: R-HSA-5620922 |
| Cellular Localisation | Cell ProjectionCilium MembraneCytoplasmCytoskeletonMicrotubule Organizing CenterCentrosomeCentriolar SatelliteCilium Basal Body |
| Alternative Antibody Names | Anti-Bbsome Complex Member Bbs7 antibodyAnti-Bbs2-Like Protein 1 antibodyAnti-Bardet-Biedl Syndrome 7 Protein antibodyAnti-BBS7 antibodyAnti-BBS2L1 antibody |
Information sourced from Uniprot.org