| Short Description : | Rabbit polyclonal ATP8B3 (600-900) antibody for use in WB and ELISA in human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications: | WB/ELISA |
| Host: | Rabbit |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Concentration: | Lot specific |
| Purification: | Affinity purification |
| Dilution Range: | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | ATP8B3 |
| Gene ID: | 148229 |
| Uniprot ID: | AT8B3_HUMAN |
| Immunogen Region: | 600-900 |
| Immunogen Sequence: | VTAARNFGYVFLSRTQDTVT IMELGEERVYQVLAIMDFNS TRKRMSVLVRKPEGAICLYT KGADTVIFERLHRRGAMEFA TEEALAAFAQETLRTLCLAY REVAEDIYEDWQQRHQEASL LLQNRAQALQQLLGATAIED RLQDGVPETIKCLKKSNIKI WVLTGDKQETAVNIGFACEL LSENMLILEEKEISRILETY WENSNNLLTRESLSQVKLAL VINGDFLDKLLVSLRKEPR |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 600-900 of human ATP8B3 (NP_620168.1). |
| Tissue Specificity | Isoform 3 was only detected in testis. |
| Function | P4-ATPase flippase which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids. Phospholipid translocation also seems to be implicated in vesicle formation and in uptake of lipid signaling molecules. May be responsible for the maintenance of asymmetric distribution of phosphatidylserine (PS) in spermatozoa membranes. Involved in acrosome reactions and binding of spermatozoa to zona pellucida. |
| Protein Name | Phospholipid-Transporting Atpase IkAtpase Class I Type 8b Member 3 |
| Database Links | Reactome: R-HSA-936837 |
| Cellular Localisation | Cytoplasmic VesicleSecretory VesicleAcrosome MembraneMulti-Pass Membrane ProteinEndoplasmic Reticulum Membrane |
| Alternative Antibody Names | Anti-Phospholipid-Transporting Atpase Ik antibodyAnti-Atpase Class I Type 8b Member 3 antibodyAnti-ATP8B3 antibodyAnti-ATP1K antibodyAnti-FOS37502_2 antibody |
Information sourced from Uniprot.org
