Anti-ATP2B2 antibody (1-80) (STJ28955)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal ATP2B2 (1-80) antibody for use in WB and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:1000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | ATP2B2 |
| Gene ID | 491 |
| Uniprot ID | AT2B2_HUMAN |
| Immunogen Region | 1-80 |
| Immunogen Sequence | MGDMTNSDFYSKNQRNESSH GGEFGCTMEELRSLMELRGT EAVVKIKETYGDTEAICRRL KTSPVEGLPGTAPDLEKRKQ |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 1-80 of human ATP2B2 (NP_001674.2). |
Additional Info
| Tissue Specificity | Mainly expressed in brain cortex. Found in low levels in skeletal muscle, heart muscle, stomach, liver, kidney and lung. Isoforms containing segment B are found in brain cortex and at low levels in other tissues. Isoforms containing segments X and W are found at low levels in all tissues. Isoforms containing segment A and segment Z are found at low levels in skeletal muscle and heart muscle. |
| Function | ATP-driven Ca(2+) ion pump involved in the maintenance of basal intracellular Ca(2+) levels in specialized cells of cerebellar circuit and vestibular and cochlear systems. Uses ATP as an energy source to transport cytosolic Ca(2+) ions across the plasma membrane to the extracellular compartment. Has fast activation and Ca(2+) clearance rate suited to control fast neuronal Ca(2+) dynamics. At parallel fiber to Purkinje neuron synapse, mediates presynaptic Ca(2+) efflux in response to climbing fiber-induced Ca(2+) rise. Provides for fast return of Ca(2+) concentrations back to their resting levels, ultimately contributing to long-term depression induction and motor learning. Plays an essential role in hearing and balance. In cochlear hair cells, shuttles Ca(2+) ions from stereocilia to the endolymph and dissipates Ca(2+) transients generated by the opening of the mechanoelectrical transduction channels. Regulates Ca(2+) levels in the vestibular system, where it contributes to the formation of otoconia. In non-excitable cells, regulates Ca(2+) signaling through spatial control of Ca(2+) ions extrusion and dissipation of Ca(2+) transients generated by store-operated channels. In lactating mammary gland, allows for the high content of Ca(2+) ions in the milk. |
| Protein Name | Plasma Membrane Calcium-Transporting Atpase 2Pmca2Plasma Membrane Calcium Atpase Isoform 2Plasma Membrane Calcium Pump Isoform 2 |
| Database Links | Reactome: R-HSA-418359Reactome: R-HSA-5578775Reactome: R-HSA-936837Reactome: R-HSA-9662360 Q01814-2Reactome: R-HSA-9662361 Q01814-2 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinSynapseIsoform Wa: Apical Cell MembraneBasolateral Cell MembraneIsoform Wb: Apical Cell MembraneIsoform Xb: Basolateral Cell MembraneIsoform Za: Basolateral Cell MembraneIsoform Zb: Basolateral Cell Membrane |
| Alternative Antibody Names | Anti-Plasma Membrane Calcium-Transporting Atpase 2 antibodyAnti-Pmca2 antibodyAnti-Plasma Membrane Calcium Atpase Isoform 2 antibodyAnti-Plasma Membrane Calcium Pump Isoform 2 antibodyAnti-ATP2B2 antibodyAnti-PMCA2 antibody |
Information sourced from Uniprot.org