| Post Translational Modifications | Autophosphorylated at the conserved aspartate of the P-type ATPase signature sequence. |
| Function | Catalytic component of P4-ATPase flippase complex, which catalyzes the hydrolysis of ATP coupled to the transport of phosphatidylcholine (PC) from the outer to the inner leaflet of the plasma membrane. Initiates inward plasma membrane bending and recruitment of Bin/amphiphysin/Rvs (BAR) domain-containing proteins involved in membrane tubulation and cell trafficking. Facilitates ITGB1/beta1 integrin endocytosis, delaying cell adhesion and cell spreading on extracellular matrix. Has low flippase activity toward glucosylceramide (GlcCer). |
| Protein Name | Phospholipid-Transporting Atpase VaAtpase Class V Type 10aAminophospholipid Translocase VaP4-Atpase Flippase Complex Alpha Subunit Atp10a |
| Database Links | Reactome: R-HSA-936837 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinEndoplasmic Reticulum MembraneExit From The Endoplasmic Reticulum Requires The Presence Of Tmem30aBut Not That Of Tmem30b |
| Alternative Antibody Names | Anti-Phospholipid-Transporting Atpase Va antibodyAnti-Atpase Class V Type 10a antibodyAnti-Aminophospholipid Translocase Va antibodyAnti-P4-Atpase Flippase Complex Alpha Subunit Atp10a antibodyAnti-ATP10A antibodyAnti-ATP10C antibodyAnti-ATPVA antibodyAnti-ATPVC antibodyAnti-KIAA0566 antibody |
Information sourced from Uniprot.org
