| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-ATG2B (1360-1600) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:1000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
ATG2B |
| Gene ID: |
55102 |
| Uniprot ID: |
ATG2B_HUMAN |
| Immunogen Region: |
1360-1600 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1360-1600 of human ATG2B (NP_060506.5). |
| Immunogen Sequence: |
IQYIASYGDLQTPNKADMKP GAFQRRSKVDSSGRSSSRGP VLPEADQQMLRDLMSDAMEE IDMQQGTSSVKPQANGVLDE KSQIQEPCCSDLFLFPDESG NVSQESGPTYASFSHHFISD AMTGVPTENDDFCILFAPKA AMQEKEEEPVIKIMVDDAIV IRDNYFSLPVNKTDTSKAPL HFPIPVIRYVVKEVSLVWHL YGGKDFGTVPPTSPAKSYIS PHSSPSHTPTRHGRNTVCG |
| Function | Lipid transfer protein required for both autophagosome formation and regulation of lipid droplet morphology and dispersion. Tethers the edge of the isolation membrane (IM) to the endoplasmic reticulum (ER) and mediates direct lipid transfer from ER to IM for IM expansion. Binds to the ER exit site (ERES), which is the membrane source for autophagosome formation, and extracts phospholipids from the membrane source and transfers them to ATG9 (ATG9A or ATG9B) to the IM for membrane expansion. Lipid transfer activity is enhanced by WDR45/WIPI4, which promotes ATG2B-association with phosphatidylinositol 3-monophosphate (PI3P)-containing membranes. |
| Protein Name | Autophagy-Related Protein 2 Homolog B |
| Cellular Localisation | Preautophagosomal Structure MembranePeripheral Membrane ProteinLipid DropletEndoplasmic Reticulum Membrane |
| Alternative Antibody Names | Anti-Autophagy-Related Protein 2 Homolog B antibodyAnti-ATG2B antibodyAnti-C14orf103 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
