| Tissue Specificity | Highly expressed in testis and at lower levels in colon, small intestine and thymus. |
| Post Translational Modifications | Phosphorylated by TLK1 and TLK2. |
| Function | Histone chaperone that facilitates histone deposition and histone exchange and removal during nucleosome assembly and disassembly. Cooperates with chromatin assembly factor 1 (CAF-1) to promote replication-dependent chromatin assembly. Also involved in the nuclear import of the histone H3-H4 dimer together with importin-4 (IPO4): specifically recognizes and binds newly synthesized histones with the monomethylation of H3 'Lys-9' (H3K9me1) and diacetylation at 'Lys-5' and 'Lys-12' of H4 (H4K5K12ac) marks in the cytosol. Does not participate in replication-independent nucleosome deposition which is mediated by ASF1A and HIRA. Required for gonad development. |
| Protein Name | Histone Chaperone Asf1bAnti-Silencing Function Protein 1 Homolog BHasf1Hasf1bCcg1-Interacting Factor A-IiCia-IiHcia-Ii |
| Cellular Localisation | NucleusCytoplasmCytosol |
| Alternative Antibody Names | Anti-Histone Chaperone Asf1b antibodyAnti-Anti-Silencing Function Protein 1 Homolog B antibodyAnti-Hasf1 antibodyAnti-Hasf1b antibodyAnti-Ccg1-Interacting Factor A-Ii antibodyAnti-Cia-Ii antibodyAnti-Hcia-Ii antibodyAnti-ASF1B antibody |
Information sourced from Uniprot.org
