| Host: | Rabbit |
| Applications: | WB/IF/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-Arrestin domain-containing protein 1 (167-216 aa) is suitable for use in Western Blot, Immunofluorescence and ELISA research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:500-2000IF 1:100-300ELISA 1:5000-20000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | ARRDC1 |
| Gene ID: | 92714 |
| Uniprot ID: | ARRD1_HUMAN |
| Immunogen Region: | 167-216 aa |
| Specificity: | Arrdc1 Polyclonal Antibody detects endogenous levels of Arrdc1 protein. |
| Immunogen: | The antiserum was produced against synthesized peptide derived from the human ARRD1 at the amino acid range 167-216 |
| Function | Functions as an adapter recruiting ubiquitin-protein ligases to their specific substrates. Through an ubiquitination-dependent mechanism plays for instance a role in the incorporation of SLC11A2 into extracellular vesicles. More generally, plays a role in the extracellular transport of proteins between cells through the release in the extracellular space of microvesicles. By participating in the ITCH-mediated ubiquitination and subsequent degradation of NOTCH1, negatively regulates the NOTCH signaling pathway. |
| Protein Name | Arrestin Domain-Containing Protein 1Alpha-Arrestin 1 |
| Cellular Localisation | Cell MembraneAlso Found In Extracellular Vesicles Different From Exosomes |
| Alternative Antibody Names | Anti-Arrestin Domain-Containing Protein 1 antibodyAnti-Alpha-Arrestin 1 antibodyAnti-ARRDC1 antibody |
Information sourced from Uniprot.org