| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Monoclonal |
| Clone ID : | S6MR |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 0.05% BSA, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:1000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | ARPC5 |
| Gene ID: | 10092 |
| Uniprot ID: | ARPC5_HUMAN |
| Immunogen Region: | 1-100 |
| Specificity: | A synthetic peptide corresponding to a sequence within amino acids 1-100 of human p16-ARC/ARC16/ARPC5 (O15511). |
| Immunogen Sequence: | MSKNTVSSARFRKVDVDEYD ENKFVDEEDGGDGQAGPDEG EVDSCLRQGNMTAALQAALK NPPINTKSQAVKDRAGSIVL KVLISFKANDIEKAVQSLDK |
| Post Translational Modifications | Polyubiquitinated by RNF128 with 'Lys-63'-linked chains, leading to proteasomal degradation. |
| Function | Component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA. The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs). |
| Protein Name | Actin-Related Protein 2/3 Complex Subunit 5Arp2/3 Complex 16 Kda SubunitP16-Arc |
| Database Links | Reactome: R-HSA-2029482Reactome: R-HSA-3928662Reactome: R-HSA-5663213Reactome: R-HSA-6798695Reactome: R-HSA-8856828Reactome: R-HSA-9664422 |
| Cellular Localisation | CytoplasmCytoskeletonCell ProjectionNucleus |
| Alternative Antibody Names | Anti-Actin-Related Protein 2/3 Complex Subunit 5 antibodyAnti-Arp2/3 Complex 16 Kda Subunit antibodyAnti-P16-Arc antibodyAnti-ARPC5 antibodyAnti-ARC16 antibody |
Information sourced from Uniprot.org