Immunohistochemistry analysis of ARPC2 in paraffin-embedded rat spleen using ARPC2 Rabbit polyclonal antibody (STJ112687) at dilution of 1:100 (40x lens). Perform high pressure antigen retrieval with 10 mM citrate buffer pH 6. 0 before commencing with immunohistochemistry staining protocol.

Anti-ARPC2 antibody (1-300) (STJ112687)

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STJ112687
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Host: Rabbit
Applications: WB/IHC-P/ELISA
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Clonality : Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3.
Purification: Affinity purification
Concentration: Lot specific
Dilution Range: WB:1:500-1:2000
IHC-P:1:50-1:200
ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements.
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: ARPC2
Gene ID: 10109
Uniprot ID: ARPC2_HUMAN
Immunogen Region: 1-300
Specificity: Recombinant fusion protein containing a sequence corresponding to amino acids 1-300 of human ARPC2 (NP_690601.1).
Immunogen Sequence: MILLEVNNRIIEETLALKFE NAAAGNKPEAVEVTFADFDG VLYHISNPNGDKTKVMVSIS LKFYKELQAHGADELLKRVY GSFLVNPESGYNVSLLYDLE NLPASKDSIVHQAGMLKRNC FASVFEKYFQFQEEGKEGEN RAVIHYRDDETMYVESKKDR VTVVFSTVFKDDDDVVIGKV FMQEFKEGRRASHTAPQVLF SHREPPLELKDTDAAVGDNI GYITFVLFPRHTNASARDN
Function Actin-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. Seems to contact the mother actin filament. In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA. The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs).
Protein Name Actin-Related Protein 2/3 Complex Subunit 2
Arp2/3 Complex 34 Kda Subunit
P34-Arc
Database Links Reactome: R-HSA-2029482
Reactome: R-HSA-3928662
Reactome: R-HSA-5663213
Reactome: R-HSA-8856828
Reactome: R-HSA-9664422
Cellular Localisation Cytoplasm
Cytoskeleton
Cell Projection
Synapse
Synaptosome
Nucleus
Alternative Antibody Names Anti-Actin-Related Protein 2/3 Complex Subunit 2 antibody
Anti-Arp2/3 Complex 34 Kda Subunit antibody
Anti-P34-Arc antibody
Anti-ARPC2 antibody
Anti-ARC34 antibody
Anti-PRO2446 antibody

Information sourced from Uniprot.org

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