Anti-ARMC5 antibody (STJA0008745)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from human ARMC5
General Information
| Short Description | Rabbit polyclonal anti-Armadillo repeat-containing protein 5 for use in WB in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | ARMC5 |
| Gene ID | 79798 |
| Uniprot ID | ARMC5_HUMAN |
| Immunogen | Synthesized peptide derived from human ARMC5 |
| Specificity | This antibody detects endogenous levels of ARMC5 at Human, Mouse, Rat |
Additional Info
| Function | Substrate-recognition component of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that terminates RNA polymerase II (Pol II) transcription in the promoter-proximal region of genes. The BCR(ARMC5) complex provides a quality checkpoint during transcription elongation by driving premature transcription termination of transcripts that are unfavorably configured for transcriptional elongation: the BCR(ARMC5) complex acts by mediating ubiquitination of Pol II subunit POLR2A phosphorylated at 'Ser-5' of the C-terminal domain (CTD), leading to POLR2A degradation. The BCR(ARMC5) complex acts in parallel of the integrator complex and is specific for RNA Pol II originating from the promoter-proximal zone: it does not ubiquitinate elongation-stalled RNA Pol II. The BCR(ARMC5) complex also acts as a regulator of fatty acid desaturation by mediating ubiquitination and degradation of SCAP-free SREBF1 and SREBF2. Involved in fetal development, T-cell function and adrenal gland growth homeostasis. Plays a role in steroidogenesis, modulates steroidogenic enzymes expression and cortisol production. |
| Protein Name | Armadillo Repeat-Containing Protein 5 |
| Database Links | |
| Cellular Localisation | NucleusChromosomeCytoplasmAssociates To Rna Polymerase Ii (Pol Ii) On Chromatin |
| Alternative Antibody Names | Anti-Armadillo Repeat-Containing Protein 5 antibodyAnti-ARMC5 antibody |
Information sourced from Uniprot.org