| Host: | Rabbit |
| Applications: | IHC/ELISA |
| Reactivity: | Human/Mouse |
| Note: | FOR SCIENTIFIC EDUCATIONAL RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR OTHER MEDICAL APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-E3 Ubiquitin-Protein Ligase Arih2 is suitable for use in Immunohistochemistry and ELISA research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.05% NaN3 and 40% Glycerol, pH7.4 |
| Purification: | Antigen affinity purification |
| Concentration: | 1.2 mg/mL |
| Dilution Range: | IHC 1:50-1:300 |
| Storage Instruction: | Store at-20°C for long term, and avoid freeze-thaw cycles. |
| Gene Symbol: | ARIH2 |
| Gene ID: | 10425 |
| Uniprot ID: | ARI2_HUMAN |
| Immunogen: | Fusion protein of human ARIH2 |
| Tissue Specificity | Widely expressed with higher expression in granulocytes. |
| Post Translational Modifications | Ubiquitinated. Ubiquitination promotes proteasomal degradation. |
| Function | E3 ubiquitin-protein ligase, which catalyzes ubiquitination of target proteins together with ubiquitin-conjugating enzyme E2 UBE2L3. Acts as an atypical E3 ubiquitin-protein ligase by working together with cullin-5-RING ubiquitin ligase complex (ECS complex, also named CRL5 complex) and initiating ubiquitination of ECS substrates: associates with ECS complex and specifically mediates addition of the first ubiquitin on ECS targets. The initial ubiquitin is then elongated. E3 ubiquitin-protein ligase activity is activated upon binding to neddylated form of the cullin-5 (CUL5) component of the ECS complex. Together with the ECS(ASB9) complex, catalyzes ubiquitination of CKB. Promotes ubiquitination of DCUN1D1. Mediates 'Lys-6', 'Lys-48'- and 'Lys-63'-linked polyubiquitination. May play a role in myelopoiesis. (Microbial infection) Following infection by HIV-1 virus, acts together with a cullin-5-RING E3 ubiquitin-protein ligase complex (ECS complex) hijacked by the HIV-1 Vif protein, to catalyze ubiquitination and degradation of APOBEC3F and APOBEC3G. |
| Protein Name | E3 Ubiquitin-Protein Ligase Arih2 Ari-2 Protein Ariadne-2 Homolog Triad1 Protein |
| Database Links | Reactome: R-HSA-983168 |
| Cellular Localisation | Nucleus Cytoplasm |
| Alternative Antibody Names | Anti-E3 Ubiquitin-Protein Ligase Arih2 antibody Anti-Ari-2 antibody Anti-Protein Ariadne-2 Homolog antibody Anti-Triad1 Protein antibody Anti-ARIH2 antibody Anti-ARI2 antibody Anti-TRIAD1 antibody Anti-HT005 antibody |
Information sourced from Uniprot.org