| Host: | Rabbit |
| Applications: | WB/IF/ICC/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000IF/ICC:1:50-1:100ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | ARHGEF26 |
| Gene ID: | 26084 |
| Uniprot ID: | ARHGQ_HUMAN |
| Immunogen Region: | 592-871 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 592-871 of human ARHGEF26 (NP_056410.3). |
| Immunogen Sequence: | ICQKTPKDSPKYEVCKRALK EVSKLVRLCNEGARKMERTE MMYTINSQLEFKIKPFPLVS SSRWLVKRGELTAYVEDTVL FSRRTSKQQVYFFLFNDVLI ITKKKSEESYNVNDYSLRDQ LLVESCDNEELNSSPGKNSS TMLYSRQSSASHLFTLTVLS NHANEKVEMLLGAETQSERA RWITALGHSSGKPPADRTSL TQVEIVRSFTAKQPDELSLQ VADVVLIYQRVSDGWYEGE |
| Tissue Specificity | Isoform 1 is broadly expressed, with highest levels in liver (at protein level). Certain mRNA species appear to be specifically expressed in prostate and liver. |
| Function | Activates RhoG GTPase by promoting the exchange of GDP by GTP. Required for the formation of membrane ruffles during macropinocytosis. Required for the formation of cup-like structures during trans-endothelial migration of leukocytes. In case of Salmonella enterica infection, activated by SopB, which induces cytoskeleton rearrangements and promotes bacterial entry. |
| Protein Name | Rho Guanine Nucleotide Exchange Factor 26Sh3 Domain-Containing Guanine Exchange Factor |
| Database Links | Reactome: R-HSA-193648Reactome: R-HSA-416482Reactome: R-HSA-9013148Reactome: R-HSA-9013408 |
| Cellular Localisation | Cell ProjectionRuffle |
| Alternative Antibody Names | Anti-Rho Guanine Nucleotide Exchange Factor 26 antibodyAnti-Sh3 Domain-Containing Guanine Exchange Factor antibodyAnti-ARHGEF26 antibodyAnti-SGEF antibodyAnti-HMFN1864 antibody |
Information sourced from Uniprot.org