Anti-ARHGEF12 antibody (449-498 aa) (STJ93900)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenThe antiserum was produced against synthesized peptide derived from the human ARHGEF12 at the amino acid range 449-498
General Information
| Short Description | Rabbit polyclonal anti-Rho guanine nucleotide exchange factor 12 (449-498 aa) for use in WB and IHC in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000IHC-P 1:50-300 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | ARHGEF12 |
| Gene ID | 23365 |
| Uniprot ID | ARHGC_HUMAN |
| Immunogen | The antiserum was produced against synthesized peptide derived from the human ARHGEF12 at the amino acid range 449-498 |
| Immunogen Region | 449-498 aa |
| Specificity | LARG Polyclonal Antibody detects endogenous levels of LARG protein. |
Additional Info
| Function | May play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13). Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase and may act as GTPase-activating protein (GAP) for GNA12 and GNA13. |
| Protein Name | Rho Guanine Nucleotide Exchange Factor 12Leukemia-Associated Rhogef |
| Database Links | Reactome: R-HSA-193648Reactome: R-HSA-416482Reactome: R-HSA-416572Reactome: R-HSA-8980692Reactome: R-HSA-9013026Reactome: R-HSA-9013106Reactome: R-HSA-9013148 |
| Cellular Localisation | CytoplasmMembraneTranslocated To The Membrane Upon Stimulation |
| Alternative Antibody Names | Anti-Rho Guanine Nucleotide Exchange Factor 12 antibodyAnti-Leukemia-Associated Rhogef antibodyAnti-ARHGEF12 antibodyAnti-KIAA0382 antibodyAnti-LARG antibody |
Information sourced from Uniprot.org