Tissue Specificity | Ubiquitously expressed. |
Post Translational Modifications | Phosphorylated by PKCA. Angiotensin-2 induced Tyr-738 phosphorylation is mediated by JAK2. |
Function | Seems to play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13) subunits. Acts as a GTPase-activating protein (GAP) for GNA12 and GNA13, and as guanine nucleotide exchange factor (GEF) for RhoA GTPase. Activated G alpha 13/GNA13 stimulates the RhoGEF activity through interaction with the RGS-like domain. This GEF activity is inhibited by binding to activated GNA12. Mediates angiotensin-2-induced RhoA activation. |
Protein Name | Rho Guanine Nucleotide Exchange Factor 1115 Kda Guanine Nucleotide Exchange FactorP115-RhogefP115rhogefSub1.5 |
Database Links | Reactome: R-HSA-193648Reactome: R-HSA-416482Reactome: R-HSA-8980692Reactome: R-HSA-9013026Reactome: R-HSA-9013106 |
Cellular Localisation | CytoplasmMembraneTranslocated To The Membrane By Activated Gna13 Or Lpa Stimulation |
Alternative Antibody Names | Anti-Rho Guanine Nucleotide Exchange Factor 1 antibodyAnti-115 Kda Guanine Nucleotide Exchange Factor antibodyAnti-P115-Rhogef antibodyAnti-P115rhogef antibodyAnti-Sub1.5 antibodyAnti-ARHGEF1 antibody |
Information sourced from Uniprot.org