Anti-ARH/LDL receptor adaptor antibody (N-Term) (STJ70389)
SPECIFICATIONS
ClonalityPolyclonal
HostGoat
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Goat polyclonal antibody anti-ARH/LDL receptor adaptor (N-Term) is suitable for use in ELISA and Immunofluorescence research applications. |
| Applications | Pep-ELISA/IF |
| Host | Goat |
| Reactivity | Human/Mouse/Rat/Dog/Cow |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 0.5 mg/mL |
| Purification | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Dilution Range | Peptide ELISA: antibody detection limit dilution 1:16000.IF: Strong expression of the protein seen in the cytoplasm of U2OS and A431 cells. Recommended concentration: 10ยตg/ml. |
| Formulation | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Storage Instruction | Store at-20ยฐC on receipt and minimise freeze-thaw cycles. |
Target Information
| Gene Symbol | LDLRAP1 |
| Gene ID | 26119 |
| Uniprot ID | ARH_HUMAN |
| Accession Number | NP_056442.2 |
| Immunogen Region | N-Term |
| Immunogen Sequence | DALKSAGRALIRS |
Additional Info
| Function | Adapter protein (clathrin-associated sorting protein (CLASP)) required for efficient endocytosis of the LDL receptor (LDLR) in polarized cells such as hepatocytes and lymphocytes, but not in non-polarized cells (fibroblasts). May be required for LDL binding and internalization but not for receptor clustering in coated pits. May facilitate the endocytosis of LDLR and LDLR-LDL complexes from coated pits by stabilizing the interaction between the receptor and the structural components of the pits. May also be involved in the internalization of other LDLR family members. Binds to phosphoinositides, which regulate clathrin bud assembly at the cell surface. Required for trafficking of LRP2 to the endocytic recycling compartment which is necessary for LRP2 proteolysis, releasing a tail fragment which translocates to the nucleus and mediates transcriptional repression. |
| Protein Name | Low Density Lipoprotein Receptor Adapter Protein 1Autosomal Recessive Hypercholesterolemia Protein |
| Database Links | Reactome: R-HSA-196791Reactome: R-HSA-8856825Reactome: R-HSA-8856828Reactome: R-HSA-8964026Reactome: R-HSA-8964038Reactome: R-HSA-9758890 |
| Cellular Localisation | Cytoplasm |
| Alternative Antibody Names | Anti-Low Density Lipoprotein Receptor Adapter Protein 1 antibodyAnti-Autosomal Recessive Hypercholesterolemia Protein antibodyAnti-LDLRAP1 antibodyAnti-ARH antibody |
Information sourced from Uniprot.org