| Function | GTPase-activating protein (GAP) for the ADP ribosylation factor 1 (ARF1). Involved in membrane trafficking and /or vesicle transport. Promotes hydrolysis of the ARF1-bound GTP and thus, is required for the dissociation of coat proteins from Golgi-derived membranes and vesicles, a prerequisite for vesicle's fusion with target compartment. Probably regulates ARF1-mediated transport via its interaction with the KDELR proteins and TMED2. Overexpression induces the redistribution of the entire Golgi complex to the endoplasmic reticulum, as when ARF1 is deactivated. Its activity is stimulated by phosphoinosides and inhibited by phosphatidylcholine. |
| Protein Name | Adp-Ribosylation Factor Gtpase-Activating Protein 1Arf Gap 1Adp-Ribosylation Factor 1 Gtpase-Activating ProteinArf1 GapArf1-Directed Gtpase-Activating Protein |
| Database Links | Reactome: R-HSA-381038Reactome: R-HSA-6807878Reactome: R-HSA-6811434Reactome: R-HSA-8856828 |
| Cellular Localisation | CytoplasmGolgi ApparatusAssociates With The Golgi Complex |
| Alternative Antibody Names | Anti-Adp-Ribosylation Factor Gtpase-Activating Protein 1 antibodyAnti-Arf Gap 1 antibodyAnti-Adp-Ribosylation Factor 1 Gtpase-Activating Protein antibodyAnti-Arf1 Gap antibodyAnti-Arf1-Directed Gtpase-Activating Protein antibodyAnti-ARFGAP1 antibodyAnti-ARF1GAP antibody |
Information sourced from Uniprot.org
