| Host: | Rabbit |
| Applications: | WB/IHC-P/IF/ICC/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Monoclonal |
| Clone ID : | S5MR |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 0.05% BSA, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:1000-1:6000 IHC-P:1:500-1:2000 IF/ICC:1:100-1:1000 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | AQP1 |
| Gene ID: | 358 |
| Uniprot ID: | AQP1_HUMAN |
| Immunogen Region: | 170-269 |
| Specificity: | A synthetic peptide corresponding to a sequence within amino acids 170-269 of human Aquaporin-1 (Aquaporin-1 (AQP1) ) (P29972). |
| Immunogen Sequence: | LAIGLSVALGHLLAIDYTGC GINPARSFGSAVITHNFSNH WIFWVGPFIGGALAVLIYDF ILAPRSSDLTDRVKVWTSGQ VEEYDLDADDINSRVEMKPK |
| Tissue Specificity | Detected in erythrocytes (at protein level). Expressed in a number of tissues including erythrocytes, renal tubules, retinal pigment epithelium, heart, lung, skeletal muscle, kidney and pancreas. Weakly expressed in brain, placenta and liver. |
| Function | Forms a water channel that facilitates the transport of water across cell membranes, playing a crucial role in water homeostasis in various tissues. Could also be permeable to small solutes including hydrogen peroxide, glycerol and gases such as amonnia (NH3), nitric oxide (NO) and carbon dioxide (CO2). Recruited to the ankyrin-1 complex, a multiprotein complex of the erythrocyte membrane, it could be part of a CO2 metabolon, linking facilitated diffusion of CO2 across the membrane, anion exchange of Cl(-)/HCO3(-) and interconversion of dissolved CO2 and carbonic acid in the cytosol. In vitro, it shows non-selective gated cation channel activity and may be permeable to cations like K(+) and Na(+) in vivo. |
| Protein Name | Aquaporin-1 Aqp-1 Aquaporin-Chip Channel-Like Integral Membrane Protein Of 28 Kda Urine Water Channel |
| Database Links | Reactome: R-HSA-1237044 Reactome: R-HSA-1247673 Reactome: R-HSA-432040 Reactome: R-HSA-432047 |
| Cellular Localisation | Cell Membrane Multi-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Aquaporin-1 antibody Anti-Aqp-1 antibody Anti-Aquaporin-Chip antibody Anti-Channel-Like Integral Membrane Protein Of 28 Kda antibody Anti-Urine Water Channel antibody Anti-AQP1 antibody Anti-CHIP28 antibody |
Information sourced from Uniprot.org