| Post Translational Modifications | Rapidly degraded by the proteasome upon overexpression of a C-terminal fragment of APP. |
| Function | Substrate-recognition component of a Cul2-RING (CRL2) E3 ubiquitin-protein ligase complex of the DesCEND (destruction via C-end degrons) pathway, which recognizes a C-degron located at the extreme C terminus of target proteins, leading to their ubiquitination and degradation. The C-degron recognized by the DesCEND pathway is usually a motif of less than ten residues and can be present in full-length proteins, truncated proteins or proteolytically cleaved forms. The CRL2(APPBP2) complex specifically recognizes proteins with a -Arg-Xaa-Xaa-Gly degron at the C-terminus, leading to their ubiquitination and degradation. The CRL2(APPBP2) complex mediates ubiquitination and degradation of truncated SELENOV selenoproteins produced by failed UGA/Sec decoding, which end with a -Arg-Xaa-Xaa-Gly degron. May play a role in intracellular protein transport: may be involved in the translocation of APP along microtubules toward the cell surface. |
| Protein Name | Amyloid Protein-Binding Protein 2Amyloid Beta Precursor Protein-Binding Protein 2App-Bp2Protein Interacting With App Tail 1 |
| Database Links | |
| Cellular Localisation | NucleusCytoplasmCytoskeletonMembranePeripheral Membrane ProteinAssociated With Membranes And Microtubules |
| Alternative Antibody Names | Anti-Amyloid Protein-Binding Protein 2 antibodyAnti-Amyloid Beta Precursor Protein-Binding Protein 2 antibodyAnti-App-Bp2 antibodyAnti-Protein Interacting With App Tail 1 antibodyAnti-APPBP2 antibodyAnti-KIAA0228 antibodyAnti-PAT1 antibody |
Information sourced from Uniprot.org
