| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:100-1:500 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | APOC2 |
| Gene ID: | 344 |
| Uniprot ID: | APOC2_HUMAN |
| Immunogen Region: | 1-101 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-101 of human APOC2 (NP_000474.2). |
| Immunogen Sequence: | MGTRLLPALFLVLLVLGFEV QGTQQPQQDEMPSPTFLTQV KESLSSYWESAKTAAQNLYE KTYLPAVDEKLRDLYSKSTA AMSTYTGIFTDQVLSVLKGE E |
| Tissue Specificity | Liver and intestine. |
| Post Translational Modifications | Proapolipoprotein C-II is synthesized as a sialic acid containing glycoprotein which is subsequently desialylated prior to its proteolytic processing. Proapolipoprotein C-II, the major form found in plasma undergoes proteolytic cleavage of its N-terminal hexapeptide to generate apolipoprotein C-II, which occurs as the minor form in plasma. |
| Function | Component of chylomicrons, very low-density lipoproteins (VLDL), low-density lipoproteins (LDL), and high-density lipoproteins (HDL) in plasma. Plays an important role in lipoprotein metabolism as an activator of lipoprotein lipase. Both proapolipoprotein C-II and apolipoprotein C-II can activate lipoprotein lipase. In normolipidemic individuals, it is mainly distributed in the HDL, whereas in hypertriglyceridemic individuals, predominantly found in the VLDL and LDL. |
| Protein Name | Apolipoprotein C-Ii Apo-Cii Apoc-Ii Apolipoprotein C2 Cleaved Into - Proapolipoprotein C-Ii Proapoc-Ii |
| Database Links | Reactome: R-HSA-8963888 Reactome: R-HSA-8963889 Reactome: R-HSA-8963901 Reactome: R-HSA-8964058 Reactome: R-HSA-9029569 Reactome: R-HSA-975634 |
| Cellular Localisation | Secreted |
| Alternative Antibody Names | Anti-Apolipoprotein C-Ii antibody Anti-Apo-Cii antibody Anti-Apoc-Ii antibody Anti-Apolipoprotein C2 Cleaved Into - Proapolipoprotein C-Ii antibody Anti-Proapoc-Ii antibody Anti-APOC2 antibody Anti-APC2 antibody |
Information sourced from Uniprot.org