| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:1000 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | APOA5 |
| Gene ID: | 116519 |
| Uniprot ID: | APOA5_HUMAN |
| Immunogen Region: | 207-366 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 207-366 of human APOA5 (NP_443200.2). |
| Immunogen Sequence: | QELHRSVAPHAPASPARLSR CVQVLSRKLTLKAKALHARI QQNLDQLREELSRAFAGTGT EEGAGPDPQMLSEEVRQRLQ AFRQDTYLQIAAFTRAIDQE TEEVQQQLAPPPPGHSAFAP EFQQTDSGKVLSKLQARLDD LWEDITHSLHDQGHSHLGDP |
| Tissue Specificity | Liver and plasma. |
| Post Translational Modifications | Phosphorylated by FAM20C in the extracellular medium. |
| Function | Minor apolipoprotein mainly associated with HDL and to a lesser extent with VLDL. May also be associated with chylomicrons. Important determinant of plasma triglyceride (TG) levels by both being a potent stimulator of apo-CII lipoprotein lipase (LPL) TG hydrolysis and an inhibitor of the hepatic VLDL-TG production rate (without affecting the VLDL-apoB production rate). Activates poorly lecithin:cholesterol acyltransferase (LCAT) and does not enhance efflux of cholesterol from macrophages. Binds heparin. |
| Protein Name | Apolipoprotein A-V Apo-Av Apoa-V Apolipoprotein A5 Regeneration-Associated Protein 3 |
| Database Links | Reactome: R-HSA-1989781 Reactome: R-HSA-381426 Reactome: R-HSA-8957275 Reactome: R-HSA-8963889 Reactome: R-HSA-8963901 |
| Cellular Localisation | Secreted Early Endosome Late Endosome Golgi Apparatus Trans-Golgi Network In The Presence Of Sorl1 Internalized To Early Endosomes Sorted In A Retrograde Fashion To Late Endosomes From Which A Portion Is Sent To Lysosomes And Degradation Another Portion Is Sorted To The Trans-Golgi Network |
| Alternative Antibody Names | Anti-Apolipoprotein A-V antibody Anti-Apo-Av antibody Anti-Apoa-V antibody Anti-Apolipoprotein A5 antibody Anti-Regeneration-Associated Protein 3 antibody Anti-APOA5 antibody Anti-RAP3 antibody Anti-UNQ411 antibody Anti-PRO773 antibody |
Information sourced from Uniprot.org